Huang Fan, Duan Jiahao, Liu Wei, Yang Chun, Yang Ling
Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Eur Arch Psychiatry Clin Neurosci. 2025 Apr 29. doi: 10.1007/s00406-025-02016-w.
The comorbidity of cardiovascular diseases (CVDs) and mental disorders (MD) has become a significant challenge in modern medicine, severely affecting patients' quality of life and prognosis. The heart-brain axis, a bidirectional pathway connecting the central nervous system and the cardiovascular system, plays a critical role in the comorbidity mechanisms of CVDs and MD. In recent years, brain-derived neurotrophic factor (BDNF) has emerged as a key molecule in the study of CVDs and MD. By binding with high affinity to TrkB receptors and activating various signaling pathways, BDNF exerts multiple functions in both the nervous and cardiovascular systems. BDNF may participate in the pathogenesis of CVDs combined with MD through multiple mechanisms such as regulating inflammatory responses, oxidative stress (OS), and the hypothalamic-pituitary-adrenal (HPA) axis, making it a promising new target for future diagnosis and treatment. This review systematically summarizes the mechanisms by which BDNF functions in heart-brain comorbidity, particularly its multifaceted influence on inflammation, OS, and neuroendocrine regulation. Additionally, we discuss the clinical application prospects of BDNF in disease diagnosis and treatment, as well as progress in related drug development. A deeper understanding of BDNF's role in the heart-brain axis will provide new insights and strategies for the prevention, diagnosis, and treatment of CVDs and MD.
心血管疾病（CVDs）与精神障碍（MD）的共病已成为现代医学中的一项重大挑战，严重影响患者的生活质量和预后。心脑轴是连接中枢神经系统和心血管系统的双向通路，在CVDs和MD的共病机制中起关键作用。近年来，脑源性神经营养因子（BDNF）已成为CVDs和MD研究中的关键分子。BDNF通过与TrkB受体高亲和力结合并激活各种信号通路，在神经和心血管系统中发挥多种功能。BDNF可能通过调节炎症反应、氧化应激（OS）和下丘脑-垂体-肾上腺（HPA）轴等多种机制参与CVDs合并MD的发病机制，使其成为未来诊断和治疗的有希望的新靶点。本综述系统总结了BDNF在心脑共病中的作用机制，特别是其对炎症、OS和神经内分泌调节的多方面影响。此外，我们还讨论了BDNF在疾病诊断和治疗中的临床应用前景以及相关药物开发的进展。深入了解BDNF在心脑轴中的作用将为CVDs和MD的预防、诊断和治疗提供新的见解和策略。
