Cinato Mathieu, Andersson Linda, Miljanovic Azra, Laudette Marion, Kunduzova Oksana, Borén Jan, Levin Malin C
Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.
Institute of Metabolic and Cardiovascular Diseases (I2MC), National Institute of Health and Medical Research (INSERM) 1297, Toulouse III University-Paul Sabatier, 31432 Toulouse, France.
Antioxidants (Basel). 2024 Feb 7;13(2):209. doi: 10.3390/antiox13020209.
Oxidative stress is the imbalance between the production of reactive oxygen species (ROS) and antioxidants in a cell. In the heart, oxidative stress may deteriorate calcium handling, cause arrhythmia, and enhance maladaptive cardiac remodeling by the induction of hypertrophic and apoptotic signaling pathways. Consequently, dysregulated ROS production and oxidative stress have been implicated in numerous cardiac diseases, including heart failure, cardiac ischemia-reperfusion injury, cardiac hypertrophy, and diabetic cardiomyopathy. Lipid droplets (LDs) are conserved intracellular organelles that enable the safe and stable storage of neutral lipids within the cytosol. LDs are coated with proteins, perilipins (Plins) being one of the most abundant. In this review, we will discuss the interplay between oxidative stress and Plins. Indeed, LDs and Plins are increasingly being recognized for playing a critical role beyond energy metabolism and lipid handling. Numerous reports suggest that an essential purpose of LD biogenesis is to alleviate cellular stress, such as oxidative stress. Given the yet unmet suitability of ROS as targets for the intervention of cardiovascular disease, the endogenous antioxidant capacity of Plins may be beneficial.
氧化应激是指细胞内活性氧（ROS）生成与抗氧化剂之间的失衡。在心脏中，氧化应激可能会使钙处理功能恶化，导致心律失常，并通过诱导肥厚和凋亡信号通路来加剧适应性不良的心脏重塑。因此，ROS生成失调和氧化应激与多种心脏疾病有关，包括心力衰竭、心脏缺血再灌注损伤、心脏肥大和糖尿病性心肌病。脂滴（LDs）是保守的细胞内细胞器，能够在细胞质中安全稳定地储存中性脂质。脂滴表面覆盖有蛋白质，其中周脂素（Plins）是含量最丰富的一种。在本综述中，我们将讨论氧化应激与周脂素之间的相互作用。事实上，脂滴和周脂素在能量代谢和脂质处理之外所发挥的关键作用正日益受到认可。大量报告表明，脂滴生物合成的一个重要目的是减轻细胞应激，如氧化应激。鉴于将ROS作为心血管疾病干预靶点的适用性尚未得到满足，周脂素的内源性抗氧化能力可能是有益的。
