Proshchina A E, Grushetskaya E O, Kharlamova A S, Godovalova O S, Krivova Yu S, Saveliev S V
Avtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, Moscow, Russia.
Bull Exp Biol Med. 2025 Mar;178(5):675-680. doi: 10.1007/s10517-025-06396-w. Epub 2025 Apr 29.
The most important transient structures in human brain are the lateral ventricle eminences, or ganglionic eminences (eminentia ventricularis lateralis), the ventral part of germinal matrix. We performed quantitative analysis of the lateral ventricle eminences to clarify the spatial and temporal dynamic of the human prenatal brain development. Serial brain sections from 9 human fetuses at gestational weeks 12-30 were examined using a morphometric method. The volume of ganglionic eminences increased during the first and early second trimesters, reached maximum at weeks 20-21, and then gradual involution of the ventral germinal matrix was observed. The obtained data are comparable with the results from noninvasive imaging techniques, but have a higher resolution.
人类大脑中最重要的短暂结构是侧脑室隆起，即神经节隆起（外侧脑室隆起），也就是生发基质的腹侧部分。我们对侧脑室隆起进行了定量分析，以阐明人类产前大脑发育的时空动态。使用形态测量方法检查了9例孕12 - 30周人类胎儿的连续脑切片。神经节隆起的体积在妊娠早期和妊娠中期的前半段增加，在第20 - 21周达到最大值，然后观察到腹侧生发基质逐渐退化。所获得的数据与非侵入性成像技术的结果具有可比性，但分辨率更高。
