Chopra Rajit, Sylvestre Marie-Pierre, Pelekanakis Annie, Doré Isabelle, Omorou Abdou Y, O'Loughlin Jennifer
École de Santé Publique, Université de Montréal, Montréal, QC, Canada.
Centre de Recherche du Centre Hospitalier Universitaire de Montréal, Montréal, QC, Canada.
Can J Public Health. 2025 Apr 29. doi: 10.17269/s41997-025-01035-3.
To describe mental health indicators according to regular (i.e., weekly or daily) alcohol, cannabis, and/or nicotine use in a population-based sample of young adults.
Data for 733 participants (mean age = 30.6 years) were drawn from cycle 23 of the ongoing Nicotine Dependence In Teens study, Montreal, Canada. The associations between (i) number of substances used and (ii) pattern of polysubstance use and each of depressive symptoms, anxiety symptoms, and positive mental health (PMH) were modeled using multivariable linear regression adjusting for age, sex, and education.
Median (IQR) scores for depressive symptoms (range 0-50), anxiety symptoms (range 0-21), and PMH (range 0-70) were 8.0 (7.0), 4.0 (6.0), and 43.0 (18.0), respectively. One third (37%) of participants did not report regular use of any substance; 42%, 16%, and 5% reported regular use of one, two, or three substances, respectively. There was no dose-response association between number of substances used and any mental health indicator. Relative to no substance use, regular use of two substances was associated with more frequent anxiety symptoms ( [95% CI] = 1.32 [0.34, 2.31]) and lower PMH (-3.64 [-6.34, -0.95]). Specifically, the cannabis-nicotine combination was associated with more frequent anxiety symptoms (2.58 [1.06, 4.10]) and lower PMH (-5.90 [-10.04, -1.76]). The alcohol-nicotine combination was associated with lower PMH (-3.70 [-7.30, -0.10]).
Specific pairings of alcohol, nicotine, and cannabis may be important in their associations with mental health. Longitudinal studies in population-based samples of young adults are needed to replicate these findings before their implications for public health programming can be considered.
在以人群为基础的年轻成年人样本中，描述根据定期（即每周或每天）使用酒精、大麻和/或尼古丁情况得出的心理健康指标。
733名参与者（平均年龄 = 30.6岁）的数据取自加拿大蒙特利尔正在进行的青少年尼古丁依赖研究的第23轮。使用多变量线性回归模型，对（i）使用物质的数量和（ii）多物质使用模式与抑郁症状、焦虑症状和积极心理健康（PMH）中的每一项之间的关联进行建模，并对年龄、性别和教育程度进行调整。
抑郁症状（范围0 - 50）、焦虑症状（范围0 - 21）和PMH（范围0 - 70）的中位数（四分位间距）得分分别为8.0（7.0）、4.0（6.0）和43.0（18.0）。三分之一（37%）的参与者未报告定期使用任何物质；42%、16%和5%的参与者分别报告定期使用一种、两种或三种物质。使用物质的数量与任何心理健康指标之间均不存在剂量反应关联。与不使用任何物质相比，定期使用两种物质与更频繁的焦虑症状（β[95%置信区间]=1.32[0.34, 2.31]）和更低的PMH（-3.64[-6.34, -0.95]）相关。具体而言，大麻 - 尼古丁组合与更频繁的焦虑症状（2.58[1.06, 4.10]）和更低的PMH（-5.90[-10.04, -1.76]）相关。酒精 - 尼古丁组合与更低的PMH（-3.70[-7.30, -0.10]）相关。
酒精、尼古丁和大麻的特定组合在其与心理健康的关联中可能很重要。在考虑其对公共卫生规划的影响之前，需要在以人群为基础的年轻成年人样本中进行纵向研究以重复这些发现。
