Magen-Rimon Ramit, Cohen Michal, Rosen Irit, Spector-Cohen Inna, Garah Jamal, Weiss Ram, Shaoul Ron
Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.
Pediatric Gastroenterology & Nutrition Institute, Ruth Children's Hospital, Rambam Medical Center, Haifa, Israel.
Dig Dis Sci. 2025 Apr 29. doi: 10.1007/s10620-025-08941-z.
Emerging evidence implicates an important role for visceral fat, particularly "creeping fat," in the pathogeneses and progression of inflammatory bowel diseases (IBD), specifically Crohn's disease (CD). In this study, we aimed to explore the association between body composition, adipocytokine profiles, and disease activity in pediatric CD patients.
We recruited patients with active and quiescent CD, aged 6-18, along with age matched healthy controls. Body composition was analyzed via bio-impedance analysis, and adipocytokines were assessed by ELISA-multiplex.
Patients with active CD exhibited significantly elevated levels of adiponectin and resistin compared to healthy controls and patients in remission even upon adjustment for body composition indices. Leptin correlated only with body composition and not with disease activity. Patients with active CD had relatively higher percentage of body fat and total body fat than the other groups.
This study underscores the complex interactions between adipocytokine profiles and disease activity in CD. Further studies are needed to investigate the potential mechanistic role of adiponectin and resistin in CD pathogenesis.
新出现的证据表明，内脏脂肪，尤其是“蔓延性脂肪”，在炎症性肠病（IBD），特别是克罗恩病（CD）的发病机制和进展中起重要作用。在本研究中，我们旨在探讨儿童CD患者的身体组成、脂肪细胞因子谱与疾病活动之间的关联。
我们招募了年龄在6至18岁的活动期和缓解期CD患者，以及年龄匹配的健康对照。通过生物电阻抗分析来分析身体组成，并通过酶联免疫吸附测定多重分析法评估脂肪细胞因子。
即使在对身体组成指标进行校正后，活动期CD患者与健康对照及缓解期患者相比，脂联素和抵抗素水平仍显著升高。瘦素仅与身体组成相关，而与疾病活动无关。活动期CD患者的体脂百分比和全身脂肪比其他组相对更高。
本研究强调了脂肪细胞因子谱与CD疾病活动之间的复杂相互作用。需要进一步研究来调查脂联素和抵抗素在CD发病机制中的潜在作用机制。
