Hasan Sana S, Fischer Andreas
Division Vascular Signaling and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Institute for Clinical Chemistry, University Medical Center Göttingen, 37075 Göttingen, Germany.
Cold Spring Harb Perspect Med. 2023 Feb 1;13(2):a041166. doi: 10.1101/cshperspect.a041166.
Formation of a functional blood vessel network is a complex process tightly controlled by pro- and antiangiogenic signals released within the local microenvironment or delivered through the bloodstream. Endothelial cells precisely integrate such temporal and spatial changes in extracellular signals and generate an orchestrated response by modulating signaling transduction, gene expression, and metabolism. A key regulator in vessel formation is Notch signaling, which controls endothelial cell specification, proliferation, migration, adhesion, and arteriovenous differentiation. This review summarizes the molecular biology of endothelial Notch signaling and how it controls angiogenesis and maintenance of the established, quiescent vasculature. In addition, recent progress in the understanding of Notch signaling in endothelial cells for controlling organ homeostasis by transcriptional regulation of angiocrine factors and its relevance to disease will be discussed.
功能性血管网络的形成是一个复杂的过程，受到局部微环境中释放的促血管生成和抗血管生成信号或通过血流传递的信号的严格控制。内皮细胞精确整合细胞外信号的这种时空变化，并通过调节信号转导、基因表达和代谢产生协调反应。血管形成中的一个关键调节因子是Notch信号，它控制内皮细胞的特化、增殖、迁移、黏附以及动静脉分化。本综述总结了内皮Notch信号的分子生物学及其如何控制血管生成和维持已建立的静止脉管系统。此外，还将讨论在理解内皮细胞中Notch信号通过血管分泌因子的转录调控来控制器官稳态及其与疾病的相关性方面的最新进展。
