Hanna W, Kahn H J
Hum Pathol. 1985 Sep;16(9):941-6. doi: 10.1016/s0046-8177(85)80133-7.
Mucoepidermoid carcinoma is a rare subtype of breast carcinoma. In an attempt to elucidate the histogenesis of these tumors, two mucoepidermoid carcinomas were studied electron microscopically and immunohistochemically with antisera to S-100 protein and epidermal cytokeratin. Light microscopic examination showed these tumors to be composed of mixtures of neoplastic mucus-secreting, squamous, and intermediate cells. Ultrastructural examination revealed squamous cells, mucus-secreting luminal cells, and classic myoepithelial cells. The intermediate cells, which contained focal peripheral myofilaments with dense bodies and pinocytotic vesicles associated with centrally aggregated tonofilaments, were interpreted as modified myoepithelial cells. Classic dendritic myoepithelial and intermediate (modified myoepithelial) cells stained with antisera to S-100 protein and epidermal cytokeratin. Both the ultrastructural and the immunohistochemical features indicate that myoepithelial and duct luminal cells play an important role in the histogenesis of mucoepidermoid tumors of the breast.
黏液表皮样癌是一种罕见的乳腺癌亚型。为了阐明这些肿瘤的组织发生，对两例黏液表皮样癌进行了电子显微镜检查，并使用抗S-100蛋白和表皮细胞角蛋白的抗血清进行免疫组织化学检查。光镜检查显示这些肿瘤由肿瘤性黏液分泌细胞、鳞状细胞和中间细胞混合组成。超微结构检查发现了鳞状细胞、黏液分泌腔细胞和典型的肌上皮细胞。中间细胞含有局灶性周边肌丝、致密小体和与中央聚集张力丝相关的吞饮小泡，被解释为改良的肌上皮细胞。典型的树突状肌上皮细胞和中间（改良肌上皮）细胞用抗S-100蛋白和表皮细胞角蛋白的抗血清染色。超微结构和免疫组织化学特征均表明，肌上皮细胞和导管腔细胞在乳腺黏液表皮样肿瘤的组织发生中起重要作用。
