Tazi Imane, Ech-Charif Soumaya, Boujida Ismail, Khmou Mouna, Mahdi Youssef, El Khannoussi Basma
Department of Pathology of the National Institute of Oncology, Ibn Sina University Hospital Center, Rabat 10100, Morocco; Faculty of Medicine and Pharmacy of Rabat, Mohamed V University, Morocco.
Department of Pathology of the National Institute of Oncology, Ibn Sina University Hospital Center, Rabat 10100, Morocco; Faculty of Medicine and Pharmacy of Rabat, Mohamed V University, Morocco.
Int J Surg Case Rep. 2025 Jun;131:111402. doi: 10.1016/j.ijscr.2025.111402. Epub 2025 May 7.
Breast mucoepidermoid carcinoma (MEC) is a very rare entity and usually underdiagnosed by the pathologists.
54-year-old woman with a single palpable mass on the left breast with no nipple discharge. She underwent tumoretomy. Microscopic examination revealed a well circumstanced intracystic proliferation consisted of mucoid, epidermoid and intermediate cells. The tumor cells were positive for ER, PR but negative for HER2.
Salivary glands like neoplasms are described in the breast, and only represent 0.2 % to 0.3 % of breast carcinomas. They usually fall under the triple negative breast carcinomas. However some cases were described in the literature with a luminal A profile. The grading score used in the salivary glands based on the presence or lack thereof nuclear anaplasia, necrosis, high mitotic activity and perineural or lymphovascular invasion seems more appropriate in this rare entity.
It is crucial for pathologists to think of this type of Breast carcinomas, especially when there is mucoid, epidermoid and intermediate cells and it does not have to fall under triple negative breast carcinomas.
乳腺黏液表皮样癌（MEC）是一种非常罕见的疾病，病理学家通常对其诊断不足。
一名54岁女性，左乳可触及单个肿块，无乳头溢液。她接受了肿瘤切除术。显微镜检查显示，肿瘤为界限清楚的囊内增殖，由黏液样、表皮样和中间细胞组成。肿瘤细胞雌激素受体（ER）、孕激素受体（PR）阳性，但人表皮生长因子受体2（HER2）阴性。
乳腺中存在类似涎腺的肿瘤，仅占乳腺癌的0.2%至0.3%。它们通常属于三阴性乳腺癌。然而，文献中也描述了一些具有腔面A型特征的病例。基于是否存在核异型性、坏死、高有丝分裂活性以及神经周围或淋巴管浸润，涎腺肿瘤使用的分级评分在这种罕见疾病中似乎更合适。
病理学家必须考虑到这类乳腺癌，特别是当存在黏液样、表皮样和中间细胞时，且它不一定属于三阴性乳腺癌。
