Stefanidis Kayla B, Schiemer Carla, Mieran Taren, Hill Andrew, Horswill Mark S, Summers Mathew J
MAIC/UniSC Road Safety Research Collaboration, University of the Sunshine Coast, Sippy Downs, Australia.
Minerals Industry Safety and Health Centre, Sustainable Minerals Institute, The University of Queensland, Brisbane, Australia.
Drug Alcohol Rev. 2025 May;44(4):1010-1023. doi: 10.1111/dar.14060. Epub 2025 Apr 29.
This program of research investigated the acute effects of orally ingested (Study 1) and vaporised (Study 2) cannabis containing delta-9-tetrahydrocannabinol (THC) on cognitive functions relevant for driving in two samples of medicinal cannabis patients (Study 1 N = 41 oral users; Study 2 N = 37 flower users).
Participants completed counterbalanced baseline (no cannabis) and cannabis consumption (post-cannabis) appointments scheduled approximately 1 week apart. During each session, participants were administered a cognitive battery assessing information processing speed, sustained and divided attention, inhibitory control and mental flexibility. In the post-cannabis condition, the battery was completed 90 min after consuming one dose of cannabis oil (Study 1) or 15 min after vaporising one dose of cannabis flower (Study 2).
In both samples, acute cannabis oil and flower administration did not induce a change in information processing speed, divided and sustained attention, or inhibitory control performance (after excluding participants with a positive drug indication at the start of either session), highlighting the moderating role of tolerance. However, significant reductions in TMT B performance were observed. Further, TMT ratio was significantly reduced post consumption of cannabis oil.
TMT B may be sensitive to acute cannabis consumption in medicinal cannabis patients. However, further research is needed to determine the nature and duration of these effects, and whether such effects vary depending on the population studied (e.g., regular vs. new users).
本研究项目调查了口服（研究1）和吸食（研究2）含Δ-9-四氢大麻酚（THC）的大麻对两组医用大麻患者驾驶相关认知功能的急性影响（研究1，N = 41名口服使用者；研究2，N = 37名吸食花朵状大麻使用者）。
参与者完成了间隔约1周安排的平衡基线（未使用大麻）和大麻消费（使用大麻后）预约。在每个阶段，参与者接受了一组认知测试，评估信息处理速度、持续和分散注意力、抑制控制和心理灵活性。在使用大麻后的情况下，在服用一剂大麻油后90分钟（研究1）或吸食一剂花朵状大麻后15分钟（研究2）完成测试。
在两个样本中，急性服用大麻油和花朵状大麻均未引起信息处理速度、分散和持续注意力或抑制控制表现的变化（在排除任一阶段开始时药物检测呈阳性的参与者后），突出了耐受性的调节作用。然而，观察到数字符号替换测验B（TMT B）表现显著下降。此外，服用大麻油后TMT比率显著降低。
TMT B可能对医用大麻患者急性服用大麻敏感。然而，需要进一步研究以确定这些影响的性质和持续时间，以及这些影响是否因研究人群而异（例如，经常使用者与新使用者）。
