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基于过去二十年的中国职业性一氧化碳中毒疾病负担趋势分析与预测

Trend analysis and prediction of disease burden of occupational carbon monoxide poisoning in China based on the past two decades.

作者信息

Xiao Yao, Wang Chaocheng, Du Yu, Zhang Qin, Xie LinShen

机构信息

West China School of Public Health and West China Fourth Hospital, Sichuan University, No.18, Section 3, Renmin South Road, Wuhou District, Chengdu, Sichuan, China.

Health Emergency Management Research Center, West China-PUMC C.C. Chen Institute of Health, Sichuan University, Chengdu, China.

出版信息

Sci Rep. 2025 Apr 29;15(1):14962. doi: 10.1038/s41598-025-99887-9.

Abstract

This study aims to analyse and predict the disease burden of occupational carbon monoxide (CO) poisoning in China and provide recommendations for its prevention and treatment. Based on the global disease burden2021 data, Joinpoint 5.0.2 software and R4.4.1 software were used to calculate the annual average percentage change (AAPC), 95% CI, and predict the disease burden of occupational CO poisoning in China in the next decade. The results show a decreasing trend in age-standardised mortality rate (ASMR) and age-standardised disability-adjusted life years (ASDR) from 2000 to 2021, with male rates consistently higher than female rates. Mortality and DALYs peak in 2021 in the 25-29 age group. ARIMA modelling projections indicate a further decline in ASMR and ASDR from 2022 to 2031. The decline in disease burden is likely to be due to advances in medical technology and improved efforts to prevent occupational diseases, but it remains higher than the global average and in several SDI regions .Further actions are needed to reduce the burden of occupational CO poisoning, including increasing the coverage of hyperbaric chambers in all regions, improving the efficiency of regulation of small and medium-sized enterprises, and strengthening CO safety training, especially for young male workers in high-risk industries.

摘要

本研究旨在分析和预测中国职业性一氧化碳(CO)中毒的疾病负担,并为其预防和治疗提供建议。基于全球疾病负担2021数据,使用Joinpoint 5.0.2软件和R4.4.1软件计算年度平均百分比变化(AAPC)、95%置信区间,并预测未来十年中国职业性CO中毒的疾病负担。结果显示,2000年至2021年期间,年龄标准化死亡率(ASMR)和年龄标准化残疾调整生命年(ASDR)呈下降趋势,男性发病率始终高于女性发病率。死亡率和伤残调整生命年在2021年25-29岁年龄组达到峰值。ARIMA模型预测表明,2022年至2031年期间ASMR和ASDR将进一步下降。疾病负担的下降可能归因于医疗技术的进步和职业病预防工作的改善,但仍高于全球平均水平,在几个社会人口指数地区也是如此。需要采取进一步行动来减轻职业性CO中毒的负担,包括提高所有地区高压氧舱的覆盖率、提高对中小企业的监管效率,以及加强CO安全培训,特别是对高危行业的年轻男性工人。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5247/12041385/32821d51cf35/41598_2025_99887_Fig1_HTML.jpg

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