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BLOSOM队列中母乳喂养婴儿出生后头两年口腔微生物群的发育情况。

Development of the breastfed infant oral microbiome over the first two years of life in the BLOSOM Cohort.

作者信息

Arishi Roaa A, Cheema Ali S, Lai Ching T, Payne Matthew S, Geddes Donna T, Stinson Lisa F

机构信息

School of Molecular Sciences, The University of Western Australia, Crawley, WA, Australia.

Australian Breastfeeding + Lactation Research and Science Translation (ABREAST) Network, Perth, WA, Australia.

出版信息

Front Cell Infect Microbiol. 2025 Apr 15;15:1534750. doi: 10.3389/fcimb.2025.1534750. eCollection 2025.

DOI:10.3389/fcimb.2025.1534750
PMID:40302925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12037575/
Abstract

BACKGROUND

Acquisition and development of the oral microbiome are dynamic processes that occur over early life. This study aimed to characterize the temporal development of the oral microbiome of predominantly breastfed infants during the first two years of life.

METHODS

Infant oral samples (n=667) were collected at ten time points from the first week to year two of life from 84 infants. Bacterial DNA profiles were analyzed using full-length 16S rRNA gene sequencing.

RESULTS

The oral microbiome was dominated by , , and . Bacterial richness decreased from 1 to 2 months (P = 0.043) and increased from 12 to 24 months (P = 0.038). Shannon diversity increased from 1 week to 1 month and again from 6 to 9 months and 9 to 12 months (all P ≤ 0.04). The composition of the infant oral microbiome was associated with multiple factors, including early pacifier use, intrapartum antibiotic prophylaxis, maternal allergy, pre-pregnancy body mass index, siblings, delivery mode, maternal age, pets at home, and birth season (all P < 0.01). Introduction of solid foods was a significant milestone in oral microbiome development, triggering an increase in bacterial diversity (richness P = 0.0004; Shannon diversity P = 0.0007), a shift in the abundance of seven species, and a change in beta diversity (P = 0.001).

CONCLUSION

These findings underscore the importance of multiple factors, particularly the introduction of solid foods, in shaping the oral microbiome of breastfed infants during early life.

摘要

背景

口腔微生物群的获取与发育是在生命早期发生的动态过程。本研究旨在描述主要母乳喂养婴儿在生命最初两年口腔微生物群的时间发育特征。

方法

从84名婴儿出生后第一周到第二年的10个时间点采集婴儿口腔样本（n = 667）。使用全长16S rRNA基因测序分析细菌DNA谱。

结果

口腔微生物群以 、 和 为主。细菌丰富度在1至2个月时下降（P = 0.043），在12至24个月时增加（P = 0.038）。香农多样性从1周增加到1个月，在6至9个月以及9至12个月时再次增加（所有P≤0.04）。婴儿口腔微生物群的组成与多种因素相关，包括早期使用安抚奶嘴、产时抗生素预防、母亲过敏、孕前体重指数、兄弟姐妹、分娩方式、母亲年龄、家中宠物和出生季节（所有P < 0.01）。固体食物的引入是口腔微生物群发育的一个重要里程碑，引发细菌多样性增加（丰富度P = 0.0004；香农多样性P = 0.0007）、七种物种丰度的变化以及β多样性的改变（P = 0.001）。

结论

这些发现强调了多种因素，特别是固体食物的引入，在塑造母乳喂养婴儿生命早期口腔微生物群方面的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6a3/12037575/c4bb9d72f99e/fcimb-15-1534750-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6a3/12037575/acba5f799371/fcimb-15-1534750-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6a3/12037575/2933d259a89c/fcimb-15-1534750-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6a3/12037575/56d0f3f97492/fcimb-15-1534750-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6a3/12037575/85a178270615/fcimb-15-1534750-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6a3/12037575/e97700678d29/fcimb-15-1534750-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6a3/12037575/b9ae0c6a1b36/fcimb-15-1534750-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6a3/12037575/e2ed17fcce1b/fcimb-15-1534750-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6a3/12037575/2933d259a89c/fcimb-15-1534750-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6a3/12037575/56d0f3f97492/fcimb-15-1534750-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6a3/12037575/f90a57229f84/fcimb-15-1534750-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6a3/12037575/3f6246f21ba0/fcimb-15-1534750-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6a3/12037575/85a178270615/fcimb-15-1534750-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6a3/12037575/c4bb9d72f99e/fcimb-15-1534750-g011.jpg

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4
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5
Season of birth and atopic dermatitis in early infancy: results from the Japan Environment and Children's Study.季节与婴儿期特应性皮炎：来自日本环境与儿童研究的结果。
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6
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7
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8
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