中国狮头鹅中新型鹅腺病毒暴发的首次报告。
First Report of a Novel Goose Adenovirus Outbreak in Lion Head Gooses in China.
作者信息
Liu Rongchang, Sun Minhua, Lan Qin, Zhang Jiaxue, Liang Qizhang, Fu Guanghua, Liao Ming, Huang Yu
机构信息
Fujian Provincial Key Laboratory for Avian Diseases Control and Prevention, Institute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agricultural Sciences, Fuzhou, China.
National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
出版信息
Transbound Emerg Dis. 2024 Feb 8;2024:3980468. doi: 10.1155/2024/3980468. eCollection 2024.
In April 2022, a novel (GoAdV) isolated from diseased Lion head gooses exhibiting swelling and hemorrhage of liver and kidney, accumulation of fluid in pericardial, in Fujian province of China. The GoAdV was propagated in goose embryo fibroblasts (GEFs), the morphological properties of the virions were studied by electron microscopy, and the full genome sequence was determined and analyzed. The results revealed that the infected cells became round and clustered like grapes, virions accumulated and were arranged in crystal lattice formations in the nucleus of GEFs with a diameter of ∼80 nm. The new isolate (named CH-FJZZ-202201) has a viral genome size of 43,480 bp and shared 96.69% sequence identity with GoAdV-4 (P29), representing the species . Phylogenetic analysis showed that CH-FJZZ-202201 was in the same genetic evolutionary branch with the viruses of and was the closest relative to GoAdV-4 P29/Hungary. This is the first report of the GoAdV-4 outside of Hungary, indicating the reemergence of new AdV strains in China.
2022年4月，在中国福建省，从患病的狮头鹅中分离出一种新型鹅腺病毒（GoAdV），这些病鹅表现出肝脏和肾脏肿胀、出血以及心包积液。该GoAdV在鹅胚成纤维细胞（GEFs）中增殖，通过电子显微镜研究了病毒粒子的形态特性，并测定和分析了全基因组序列。结果显示，被感染的细胞变得圆润且像葡萄一样聚集在一起，病毒粒子在直径约80nm的GEFs细胞核中积累并呈晶格状排列。新分离株（命名为CH-FJZZ-202201）的病毒基因组大小为43480bp，与GoAdV-4（P29）的序列同一性为96.69%，属于该种。系统发育分析表明，CH-FJZZ-202201与 和 的病毒处于同一遗传进化分支，与GoAdV-4 P29/匈牙利株亲缘关系最近。这是匈牙利以外首次报道GoAdV-4，表明中国出现了新的腺病毒毒株。
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