Sajedi Parvin, Travati Amir Mohammad
Department of Anesthesiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2025 Mar 28;14:29. doi: 10.4103/abr.abr_84_24. eCollection 2025.
This study was conducted with the aim of determining the effect of pre-emptive dose of dexamethasone on pain, nausea, frequency of vomiting, and restlessness after septorhinoplasty.
In this clinical trial study, 70 patients' candidates for septorhinoplasty were divided into two groups of 35 and before induction of anesthesia, 0.1 mg/kg of dexamethasone was injected intravenously in the first group and the same volume of normal saline in the second group. Postoperative nausea severity and frequency of vomiting, pain intensity, patient restlessness, painkiller, and antinausea medication usage up to 24 hours after surgery were evaluated and compared in two groups.
There was a significant difference between the two groups in the mean of pain intensity at the time of recovery (0.031). Also, 6 hours ( = 0.016), 12 hours (P=<0.001), 18 hours ( = 0.013), and 24 ( = 0.009) hours after the operation, the control group had higher pain intensity. In recovery, 9 (28.1%) of the dexamethasone group and 22 (66.7%) of the control group had restlessness ( = 0.002). Severity of nausea from PACU until 24 hours after surgery showed that the dexamethasone group had less nausea at the PACU (P ˂ 0.001); three subjects from this group have vomited and seven subjects from the control group vomited after surgery, and differences were not significant ( = 0.3).
Intravenous dexamethasone 0.1 mg/kg before induction of anesthesia reduced the intensity of pain, nausea, restlessness, and the need for painkillers and antinausea drugs, without causing serious hemodynamic disorders. It seems that the use of this drug with the mentioned dose in septorinoplasty patients is associated with a reduction in postoperative complications.
本研究旨在确定地塞米松的预先给药剂量对鼻中隔成形术后疼痛、恶心、呕吐频率和躁动的影响。
在这项临床试验研究中，70例鼻中隔成形术候选患者被分为两组，每组35例。在麻醉诱导前，第一组静脉注射0.1mg/kg地塞米松，第二组注射相同体积的生理盐水。评估并比较两组术后24小时内的恶心严重程度、呕吐频率、疼痛强度、患者躁动情况、止痛药和抗恶心药物的使用情况。
两组在恢复时的平均疼痛强度存在显著差异（0.031）。此外，术后6小时（P = 0.016）、12小时（P<0.001）、18小时（P = 0.013）和24小时（P = 0.009），对照组的疼痛强度更高。在恢复过程中，地塞米松组有9例（28.1%）出现躁动，对照组有22例（66.7%）出现躁动（P = 0.002）。从麻醉后恢复室（PACU）到术后24小时的恶心严重程度表明，地塞米松组在PACU时恶心较少（P＜0.001）；该组有3例患者术后呕吐，对照组有7例患者术后呕吐，差异无统计学意义（P = 0.3）。
麻醉诱导前静脉注射0.1mg/kg地塞米松可降低疼痛强度、恶心、躁动以及对止痛药和抗恶心药物的需求，且不会引起严重的血流动力学紊乱。在鼻中隔成形术患者中使用该剂量的这种药物似乎与术后并发症的减少有关。
