Ramezanian Maryam, Bagheri Toolaroud Parissa, Emiralavi Cyrus, Farzin Mohaya, Mobayen Mohammadreza, Moghaddam Ahmadi Moein, Tolouei Mohammad, Rimaz Siamak, Karimian Mehdi, Eftekhari Hojat, Baghi Kiana, Shabbak Ali
Burn and Regenerative Medicine Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Medical Education Research Center, Education Development Center, Guilan University of Medical Sciences, Rasht, Iran.
Bull Emerg Trauma. 2025;13(1):47-52. doi: 10.30476/beat.2025.102250.1506.
Severe burns often result in significant intravascular albumin loss, leading to hypoalbuminemia. This study aimed to evaluate the association between serum albumin levels and clinical outcomes in burn patients.
A retrospective, single-center study was conducted at Velayat Hospital (Rasht, Iran), including burn patients aged ≥16 years, who were admitted between April 2019 and March 2020. Serum albumin levels were recorded on day 1, day 7, and at discharge. The main variables analyzed included albumin levels, length of hospital stay, skin graft rate, need for mechanical ventilation, and mortality.
Among the 74 patients included in the study, 14 (18.9%) died, while 60 (81.1%) survived. The mean serum albumin levels on days 1, 7, and at discharge were significantly higher in survivors (3.09±0.22, 3.12±0.23, and 3.18±0.28 g/dL, respectively) than non-survivors (2.22±0.29, 2.74±0.29, and 2.07±0.69 g/dL, respectively) at all time points (<0.001). The serum albumin level measured on day 1 was significantly lower in patients who required mechanical ventilation than in those who did not (2.86±0.47 vs.3.09±0.13, =0.03). Additionally, a significant inverse relationship was observed between serum albumin levels and both total body surface area burned (TBSA) and graft extent (day 1: r=-0.76, day 7: r=-0.74, discharge: r=-0.62; <0.001 for TBSA; and day 1: r=-0.59, day 7: r=-0.58, discharge: r=-0.50; <0.001 for graft extent).
Hypoalbuminemia was associated with poor clinical outcomes in patients with severe burns. Serum albumin levels might serve as a specific marker of burn severity and a predictor of mortality.
严重烧伤常导致血管内白蛋白大量丢失，从而引发低白蛋白血症。本研究旨在评估烧伤患者血清白蛋白水平与临床结局之间的关联。
在伊朗拉什特市的韦拉亚特医院开展了一项回顾性单中心研究，纳入2019年4月至2020年3月期间收治的年龄≥16岁的烧伤患者。记录患者第1天、第7天及出院时的血清白蛋白水平。分析的主要变量包括白蛋白水平、住院时间、植皮率、机械通气需求及死亡率。
本研究纳入的74例患者中，14例（18.9%）死亡，60例（81.1%）存活。在所有时间点，存活者第1天、第7天及出院时的平均血清白蛋白水平（分别为3.09±0.22、3.12±0.23和3.18±0.28 g/dL）均显著高于非存活者（分别为2.22±0.29、2.74±0.29和2.07±0.69 g/dL）（<0.001）。需要机械通气的患者第1天测得的血清白蛋白水平显著低于不需要机械通气的患者（2.86±0.47 vs.3.09±0.13，P =0.03）。此外，血清白蛋白水平与烧伤总面积（TBSA）和植皮范围均呈显著负相关（第1天：r=-0.76，第7天：r=-0.74，出院时：r=-0.62；TBSA的P<0.001；第1天：r=-0.59，第7天：r=-0.58，出院时：r=-0.50；植皮范围的P<0.001）。
低白蛋白血症与严重烧伤患者的不良临床结局相关。血清白蛋白水平可能是烧伤严重程度的特异性标志物及死亡率的预测指标。
