Montano Monty
Harvard Medical School, Boston, Massachusetts, USA.
Aging Cell. 2025 Jun;24(6):e70089. doi: 10.1111/acel.70089. Epub 2025 Apr 30.
Aging is typically framed by disease, not resilience. This Perspective highlights immune resilience (IR) as a core determinant of healthy aging, based on new findings linking TCF7-driven immune profiles to extended healthspan and lifespan. IR buffers against immunosenescence, inflammaging, and senescent cell phenotypes, with benefits most pronounced before age 70. By reframing aging around salutogenesis rather than pathogenesis, this work shifts the focus toward resilience mechanisms and composite traits preserving health.
衰老通常以疾病为框架，而非恢复力。这一观点强调免疫恢复力（IR）是健康衰老的核心决定因素，基于将TCF7驱动的免疫特征与延长的健康寿命和寿命相联系的新发现。IR可缓冲免疫衰老、炎症衰老和衰老细胞表型，其益处在70岁之前最为明显。通过将衰老围绕健康生成而非发病机制进行重新构建，这项工作将重点转向了维持健康的恢复力机制和复合特征。
