Wang Ruoning, Wu Dandan, Wang Chunqing, Livingston Amanda, Wu Xiang, Liu Meilian, Yang Xuexian O
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Biomolecules. 2025 Mar 26;15(4):482. doi: 10.3390/biom15040482.
Microbial, especially fungal, sensitization has been associated with the development and exacerbation of treatment-refractory neutrophilic asthma. Among the airway-inhabiting fungi, and are the dominant species that elicit protective T helper (Th) 17 and other T cell responses, contributing to airway neutrophilia and steroid resistance. However, it is not fully understood how fungal airway colonization impacts the immunopathogenesis of asthma. Here, we used a neutrophilic asthma model induced by to study the immune regulation of this disease. We found that intranasal administration of induced platelet infiltration into the lung. Platelet-expressed latent TGF-β could be activated specifically by Th17 cells and drive the commitment, maintenance, and expansion of Th17 cells. In Candida-induced asthma, an adoptive transfer of platelets enhanced Th17 responses, increasing airway neutrophil influx. Thus, managing airway mycobiota and reducing platelet intrapulmonary infiltration may serve as a promising interventional approach.
微生物致敏，尤其是真菌致敏，与治疗抵抗性嗜中性粒细胞性哮喘的发生和加重有关。在栖息于气道的真菌中，和是引发保护性辅助性T细胞（Th）17及其他T细胞反应的主要菌种，会导致气道嗜中性粒细胞增多和类固醇抵抗。然而，真菌在气道定植如何影响哮喘的免疫发病机制尚未完全明确。在此，我们使用诱导的嗜中性粒细胞性哮喘模型来研究该疾病的免疫调节。我们发现经鼻给予会诱导血小板浸润到肺中。血小板表达的潜伏性转化生长因子-β（TGF-β）可被Th17细胞特异性激活，并驱动Th17细胞的定向分化、维持和扩增。在念珠菌诱导的哮喘中，过继转移血小板可增强Th17反应，增加气道嗜中性粒细胞流入。因此，管理气道真菌群和减少血小板肺内浸润可能是一种有前景的干预方法。
