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将蛇咬伤抗蛇毒血清治疗下放至巴西亚马逊地区的本土社区卫生中心:从需求到首次治疗(拯救计划)。

Decentralization of snakebite antivenom treatment to indigenous community health centers in the Brazilian Amazon: From demand to the first treatment (the SAVING Program).

作者信息

Seabra de Farias Altair, Serrão-Pinto Thiago, Cardoso Deugles, Augusto Guimarães Figueira Elder, Almeida-Val Fernando, Amorim Ramos Tatyana, Dourado Flávio Santos, Ferreira de Lima-Junior Francisco Edilson, Montebello Lucia, Rodrigues Gomes Filho Manoel, da Silva Ipuchima Leonardo, Ferreira de Souza Nilzoney, da Costa Arévalo Macio, Lacerda Marcus, Azevedo Machado Vinícius, Murta Felipe, Gerardo Charles, Vissoci João, Hui Wen Fan, Sachett Jacqueline, Monteiro Wuelton

机构信息

School of Health Sciences, Universidade do Estado do Amazonas, Manaus, Brazil.

Department of Teaching and Research, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.

出版信息

PLoS Negl Trop Dis. 2025 Apr 30;19(4):e0013011. doi: 10.1371/journal.pntd.0013011. eCollection 2025 Apr.

Abstract

Brazilian antivenoms have excellent efficacy in recovering venom-induced coagulopathy, in addition to having a good safety profile with only 10% of patients experiencing a mild reaction such as urticaria or pruritus. More than 3.5 hundred thousand snakebite antivenom vials are produced per year, and all the batches are acquired by the Ministry of Health and distributed free of charge to 2,200 hospitals across the national territory. However, these health facilities are unevenly distributed across the territory, so that the distance a patient needs to travel to receive care is much greater in the Amazon region in comparison to the extra-Amazonia region, leading to a huge access barrier in this region. The lack of access to healthcare facilities for snakebite patients may be greater than 30% in some regions of the Amazonia. The decentralization of SBE treatment with antivenoms to the scope of indigenous community health centers requires the discussion of proper organizational designs and arrangements of practices based on the user needs, singularities of the territory, and the clinical reality of the indigenous populations. In this report, we describe a successful experience of decentralization of antivenom treatment for an indigenous health unit in the Brazilian Amazon, which provides a platform to improve the lives of SBE patients at risk of this life-threatening condition. In this work, we report the experience in the development and implementation of a program to decentralize antivenom treatment for indigenous communities, which represents a significant change in the national policy for snakebite control, with a potential impact on reducing morbidity and mortality from this health problem. In the next steps, SAVING Program will be evaluated through mixed-method studies in regards team and community's experience within the program, aiming to identify barriers, perceptions about the implementation process, and facilitators for the maintenance/sustainability.

摘要

巴西抗蛇毒血清在恢复蛇毒引起的凝血病方面具有出色的疗效,此外安全性良好,只有10%的患者会出现如荨麻疹或瘙痒等轻微反应。每年生产超过35万瓶蛇咬抗蛇毒血清,所有批次均由卫生部采购并免费分发给全国2200家医院。然而,这些医疗机构在全国分布不均,因此与亚马孙地区以外的地区相比,亚马孙地区的患者接受治疗所需的行程要长得多,这导致该地区存在巨大的就医障碍。在亚马孙地区某些地方,蛇咬患者无法获得医疗设施的比例可能超过30%。将抗蛇毒血清治疗蛇咬伤的工作下放到土著社区卫生中心的范围,需要根据用户需求、地区特点和土著居民的临床实际情况,讨论适当的组织设计和实践安排。在本报告中,我们描述了巴西亚马孙地区一个土著卫生单位抗蛇毒血清治疗下放的成功经验,这为改善面临这种危及生命疾病风险的蛇咬伤患者的生活提供了一个平台。在这项工作中,我们报告了为土著社区制定和实施抗蛇毒血清治疗下放计划的经验,这代表了国家蛇咬伤控制政策的重大变化,可能对降低这一健康问题的发病率和死亡率产生影响。在接下来的步骤中,将通过混合方法研究对“拯救”计划进行评估,内容涉及该计划中团队和社区的经验,旨在确定障碍、对实施过程的看法以及维持/可持续性的促进因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73d7/12043230/413dc7c2bdbb/pntd.0013011.g001.jpg

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