Esmaeilpour Donya, Zare Ehsan Nazarzadeh, Hassanpur Mahnaz, Sher Farooq, Sillanpää Mika
Center for Nanotechnology in Drug Delivery, School of Pharmacy, Shiraz University of Medical Science, Shiraz, 71345-1583, Iran.
School of Chemistry, Damghan University, Damghan 36716-45667, Iran; Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura 140401, Punjab, India.
Nanomedicine. 2025 Jul;67:102821. doi: 10.1016/j.nano.2025.102821. Epub 2025 Apr 28.
Integrating artificial intelligence (AI) with nanomedicine is transforming Theranostics, driving advances in biosensing, bioimaging, genomics, diagnostics, and treatment. This review highlights the latest advancements in AI-driven nanomedicine, focusing on its transformative impact on healthcare. AI-integrated biosensors offer ultra-sensitive, real-time biomaterial detection, reducing false positives by 40 %. In bioimaging, AI algorithms improve resolution to 10 nm, particularly in gold nanoparticles (AuNP)-based imaging. AuNPs, leveraging surface plasmon resonance (SPR), act as contrast agents for early disease detection. AI accelerates genomic analysis, increasing sequencing accuracy by 30 %, enhancing biomarker identification for personalized medicine. AI powered diagnostics ensure rapid, non-invasive pathogen detection within 30 min with 95 % accuracy. AI-driven drug delivery systems enable precise, controlled release, reducing side effects by 20 %. This review explores AI-enhanced AuNPs in biosensing, bioimaging, genomics, diagnostics, and therapy while addressing challenges like scalability, biocompatibility. AI's role in Nanomedicine underscores its potential to revolutionize personalized medicine and future healthcare innovations.
将人工智能（AI）与纳米医学相结合正在改变治疗诊断学，推动生物传感、生物成像、基因组学、诊断和治疗等领域的进步。本综述重点介绍了人工智能驱动的纳米医学的最新进展，着重阐述其对医疗保健的变革性影响。集成人工智能的生物传感器可提供超灵敏的实时生物材料检测，将假阳性率降低40%。在生物成像方面，人工智能算法将分辨率提高到10纳米，特别是在基于金纳米颗粒（AuNP）的成像中。利用表面等离子体共振（SPR）的金纳米颗粒可作为早期疾病检测的造影剂。人工智能加速基因组分析，将测序准确率提高30%，增强了用于个性化医疗的生物标志物识别。由人工智能驱动的诊断可确保在30分钟内快速、无创地检测病原体，准确率达95%。人工智能驱动的药物递送系统能够实现精确、可控的释放，将副作用降低20%。本综述探讨了人工智能增强的金纳米颗粒在生物传感、生物成像、基因组学、诊断和治疗中的应用，同时也讨论了诸如可扩展性、生物相容性等挑战。人工智能在纳米医学中的作用凸显了其变革个性化医疗和未来医疗创新的潜力。
