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匐行脂肪:小肠克罗恩病中一个有前景的影像学预测指标。

Creeping fat: A promising radiological predictor in small bowel Crohn's disease.

作者信息

Wei Hong, Mai Zi-Ling, Ma Bo-Tong, Chang Bing

机构信息

Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.

出版信息

World J Gastroenterol. 2025 Apr 28;31(16):105186. doi: 10.3748/wjg.v31.i16.105186.

DOI:10.3748/wjg.v31.i16.105186
PMID:40308808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12038524/
Abstract

In this manuscript, we comment on the article by Hasnaoui . Specifically, we delve into the characteristic manifestation of Crohn's disease (CD) known as creeping fat (CF). Our primary focus is to investigate the potential of imaging features of CF in predicting the response of small bowel CD to biologic therapies and fecal microbiota transplantation. We believe that further research should be dedicated to developing methods for quantifying CF in order to provide more accurate predictive tools for the treatment of small bowel CD.

摘要

在本手稿中,我们对哈斯纳维的文章进行评论。具体而言,我们深入探讨了克罗恩病(CD)的特征性表现——匐行脂肪(CF)。我们的主要重点是研究CF的影像学特征在预测小肠CD对生物疗法和粪便微生物群移植反应方面的潜力。我们认为,应进一步开展研究以开发量化CF的方法,从而为小肠CD的治疗提供更准确的预测工具。

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Creeping fat: A promising radiological predictor in small bowel Crohn's disease.匐行脂肪:小肠克罗恩病中一个有前景的影像学预测指标。
World J Gastroenterol. 2025 Apr 28;31(16):105186. doi: 10.3748/wjg.v31.i16.105186.
2
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J Inflamm Res. 2025 Jun 11;18:7631-7649. doi: 10.2147/JIR.S524671. eCollection 2025.
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本文引用的文献

1
Ileal Predominance in Crohn's Disease Is Associated With Increased Intestinal Surgery and Biological Therapy Use, With Lower Treatment Persistence.克罗恩病以回肠为主与肠道手术增加、生物治疗使用增加以及治疗持续性降低相关。
Am J Gastroenterol. 2025 Jan 1;120(1):194-203. doi: 10.14309/ajg.0000000000003207. Epub 2024 Nov 14.
2
Gut microbiota and mesenteric adipose tissue interactions in shaping phenotypes and treatment strategies for Crohn's disease.肠道微生物群与肠系膜脂肪组织在塑造克罗恩病表型及治疗策略中的相互作用
World J Gastroenterol. 2024 Dec 14;30(46):4969-4976. doi: 10.3748/wjg.v30.i46.4969.
3
Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn's disease.微生物诱导的巨噬细胞中犬尿氨酸代谢改变导致克罗恩病中匍匐性脂肪的形成。
Cell Host Microbe. 2024 Nov 13;32(11):1927-1943.e9. doi: 10.1016/j.chom.2024.10.008.
4
Ultrasound Characteristics Can Predict Response to Biologics Therapy in Stricturing Crohn's Disease.超声特征可预测狭窄型克罗恩病对生物制剂治疗的反应。
Clin Transl Gastroenterol. 2024 Aug 1;15(8):e00738. doi: 10.14309/ctg.0000000000000738.
5
Taking Microbiome Science to the Next Level: Recommendations to Advance the Emerging Field of Microbiome-Based Therapeutics and Diagnostics.将微生物组科学提升到新高度:推动基于微生物组的治疗与诊断这一新兴领域发展的建议。
Gastroenterology. 2024 Nov;167(6):1059-1064. doi: 10.1053/j.gastro.2024.05.023. Epub 2024 May 28.
6
CT energy spectral parameters of creeping fat in Crohn's disease and correlation with inflammatory activity.克罗恩病中匐行脂肪的CT能谱参数及其与炎症活动的相关性
Insights Imaging. 2024 Jan 17;15(1):10. doi: 10.1186/s13244-023-01592-6.
7
CT enterography-based radiomics combined with body composition to predict infliximab treatment failure in Crohn's disease.基于 CT 肠造影的放射组学与人体成分相结合预测克罗恩病英夫利昔单抗治疗失败。
Radiol Med. 2024 Feb;129(2):175-187. doi: 10.1007/s11547-023-01748-w. Epub 2023 Nov 20.
8
Gut microbiome, metabolome, host immunity associated with inflammatory bowel disease and intervention of fecal microbiota transplantation.肠道微生物组、代谢组、宿主免疫与炎症性肠病的关系及粪便微生物移植的干预作用。
J Autoimmun. 2023 Dec;141:103062. doi: 10.1016/j.jaut.2023.103062. Epub 2023 May 27.
9
Creeping fat formation and interaction with intestinal disease in Crohn's disease.克罗恩病中 creeping fat 的形成及其与肠道疾病的相互作用。
United European Gastroenterol J. 2022 Dec;10(10):1077-1084. doi: 10.1002/ueg2.12349. Epub 2022 Dec 12.
10
Anti-TNF Therapies Suppress Adipose Tissue Inflammation in Crohn's Disease.抗 TNF 治疗可抑制克罗恩病患者的脂肪组织炎症。
Int J Mol Sci. 2022 Sep 22;23(19):11170. doi: 10.3390/ijms231911170.