Yang Heng, He Zhijiang, Lai Jianfen, Yang Jing, Huang Qianrong, Chang Ying, Tian Mingyuan, Huang Hongli
Department of Obstetrics and Gynecology, Shenzhen Luohu Maternity and Child Health Hospital, Shenzhen, China.
Department of Paediatrics, Shenzhen University General Hospital, Shenzhen, China.
Front Microbiol. 2025 Apr 16;16:1567721. doi: 10.3389/fmicb.2025.1567721. eCollection 2025.
Hypertensive disorders of pregnancy (HDP) pose significant risks to both maternal and fetal health and have been associated with alterations in the maternal gut microbiota. However, the impact of HDP on neonatal microbiota remains poorly understood. This study aimed to characterize the gut microbiota of pregnant women with HDP and evaluate its potential influence on the meconium microbiota of their newborns.
A cohort of 67 pregnant women, including 36 diagnosed with HDP (HDP group) and 31 healthy, age-matched controls (HC group), along with their offspring, were recruited. Fecal samples collected during the third trimester and meconium samples from the newborns were subjected to microbial community profiling via 16S rRNA gene sequencing.
Principal coordinate analysis (PCoA) based on Bray-Curtis distances revealed significant differences in microbial community composition between the HDP and HC groups in both maternal and neonatal samples. Subgroup analyses, stratified by HDP severity and medication use, further delineated distinct microbial profiles relative to controls. Notably, both maternal and neonatal microbiota in the HDP group exhibited increased abundances of , , and , coupled with a reduction in , , , , , and compared to the HC group. Moreover, the P4-PWY pathway, which is involved in the biosynthesis of L-lysine, L-threonine, and L-methionine, was differentially represented in both maternal and neonatal microbiota in the HDP group. These parallel patterns suggest an intergenerational concordance associated with HDP.
This study demonstrates significant alterations in the microbial communities of both maternal fecal and neonatal meconium samples in the context of HDP. The findings highlight the importance of further research to elucidate the long-term health implications of HDP-associated microbiota shifts on offspring.
妊娠期高血压疾病（HDP）对母婴健康构成重大风险，并与母体肠道微生物群的改变有关。然而，HDP对新生儿微生物群的影响仍知之甚少。本研究旨在表征患有HDP的孕妇的肠道微生物群，并评估其对新生儿胎粪微生物群的潜在影响。
招募了67名孕妇及其后代，其中包括36名被诊断为HDP的孕妇（HDP组）和31名年龄匹配的健康对照者（HC组）。对妊娠晚期采集的粪便样本和新生儿的胎粪样本进行16S rRNA基因测序，以分析微生物群落。
基于Bray-Curtis距离的主坐标分析（PCoA）显示，HDP组和HC组的母体和新生儿样本中的微生物群落组成存在显著差异。按HDP严重程度和用药情况分层的亚组分析进一步描绘了与对照组相比不同的微生物谱。值得注意的是，与HC组相比，HDP组的母体和新生儿微生物群中，[具体菌属1]、[具体菌属2]和[具体菌属3]的丰度增加，而[具体菌属4]、[具体菌属5]、[具体菌属6]、[具体菌属7]、[具体菌属8]和[具体菌属9]的丰度降低。此外，参与L-赖氨酸、L-苏氨酸和L-蛋氨酸生物合成的P4-PWY途径在HDP组的母体和新生儿微生物群中表现出差异。这些平行模式表明与HDP相关的代际一致性。
本研究表明，在HDP情况下，母体粪便和新生儿胎粪样本中的微生物群落发生了显著变化。这些发现突出了进一步研究以阐明HDP相关微生物群变化对后代长期健康影响的重要性。
