Meyer J S, Tanahashi N, Ishikawa Y, Hata T, Velez M, Fann W E, Kandula P, Mortel K F, Rogers R L
J Cereb Blood Flow Metab. 1985 Sep;5(3):376-85. doi: 10.1038/jcbfm.1985.52.
Nineteen patients with sudden onset of impaired recent memory, cerebellar ataxia, peripheral neuropathy, and other signs of Wernicke-Korsakoff syndrome (WKS) were treated and examined prospectively for 3 months. Serial studies included histories, neurological examinations, cognitive capacity screening examinations (CCSE), computed tomography (CT) scans, and measurements of regional CBF. Patients were detoxified and withdrawn from sedatives before CBF measurements were examined. Treatment included alcohol withdrawal, nutritious diet, and 300 mg thiamine daily. Before treatment CCSE scores and blood flow values of both white and gray matter were reduced, particularly within both temporoparietal regions. After treatment of compliant patients (n = 10), white and gray matter blood flow increased concurrently with improved CCSE scores. Abnormal eye signs, ataxia, peripheral neuropathy, and performance of activities of daily living also improved. Cerebral atrophy and ventricular enlargement measured by CT decreased. Early recognition and treatment of WKS in compliant patients permit rapid reversals of cognitive and neurological impairments associated with increased blood flow of gray and white matter and improvements of brain atrophy measured by CT scanning.
对19例近期记忆力受损、小脑共济失调、周围神经病变以及出现其他韦尼克 - 科尔萨科夫综合征（WKS）体征的突发患者进行了为期3个月的前瞻性治疗与检查。系列研究包括病史采集、神经学检查、认知能力筛查检查（CCSE）、计算机断层扫描（CT）以及局部脑血流量（CBF）测量。在进行CBF测量检查前，先让患者解毒并停用镇静剂。治疗措施包括戒酒、营养饮食以及每日300毫克硫胺素。治疗前，CCSE评分以及白质和灰质的血流值均降低，尤其是在双侧颞顶叶区域。在对依从性好的患者（n = 10）进行治疗后，白质和灰质血流增加，同时CCSE评分提高。异常眼征、共济失调、周围神经病变以及日常生活活动能力也有所改善。CT测量的脑萎缩和脑室扩大减轻。对依从性好的患者早期识别并治疗WKS，可使与灰质和白质血流增加相关的认知和神经功能障碍迅速逆转，并改善CT扫描测量的脑萎缩情况。
