Chan Y W, McLeod J G, Tuck R R, Feary P A
J Neurol Neurosurg Psychiatry. 1985 Nov;48(11):1107-12. doi: 10.1136/jnnp.48.11.1107.
Brain stem auditory evoked responses (BAERs) were performed on 25 alcoholic patients with Wernicke-Korsakoff syndrome, 56 alcoholic patients without Wernicke-Korsakoff syndrome, 24 of whom had cerebellar ataxia, and 37 control subjects. Abnormal BAERs were found in 48% of patients with Wernicke-Korsakoff syndrome, in 25% of alcoholic patients without Wernicke-Korsakoff syndrome but with cerebellar ataxia, and in 13% of alcoholic patients without Wernicke-Korsakoff syndrome or ataxia. The mean value of the I-V interval was prolonged in all patient groups. There were more patients with prolonged I-V and I-III intervals in the Wernicke-Korsakoff syndrome group than in the group without the syndrome. The I-III interval was prolonged in 32% of those with Wernicke-Korsakoff syndrome but in only 6% of alcoholics without the syndrome. These abnormalities improved following thiamine treatment and abstinence from alcohol. The presence of prolonged I-III interval in an alcoholic should raise the possibility of Wernicke's encephalopathy.
对25例患有韦尼克-科尔萨科夫综合征的酒精性患者、56例未患韦尼克-科尔萨科夫综合征的酒精性患者（其中24例有小脑共济失调）以及37名对照者进行了脑干听觉诱发电位（BAERs）检测。结果发现，48%的韦尼克-科尔萨科夫综合征患者、25%未患韦尼克-科尔萨科夫综合征但有小脑共济失调的酒精性患者以及13%未患韦尼克-科尔萨科夫综合征或共济失调的酒精性患者存在异常的BAERs。所有患者组的I-V间期平均值均延长。与未患该综合征的组相比，韦尼克-科尔萨科夫综合征组中I-V和I-III间期延长的患者更多。32%的韦尼克-科尔萨科夫综合征患者I-III间期延长，而未患该综合征的酒精性患者中只有6%出现这种情况。这些异常在硫胺素治疗和戒酒之后有所改善。酒精性患者出现I-III间期延长应提高韦尼克脑病的可能性。
