Ishikawa Y, Meyer J S, Tanahashi N, Hata T, Velez M, Fann W E, Kandula P, Motel K F, Rogers R L
J Cereb Blood Flow Metab. 1986 Feb;6(1):86-94. doi: 10.1038/jcbfm.1986.11.
Twenty severe chronic alcoholic patients with signs of neurotoxicity but without Wernicke-Korsakoff syndrome were treated by abstinence from alcohol and examined prospectively at intervals thereafter. Serial examinations included detailed medical histories, neurological examinations, cognitive capacity screening examinations, computed tomography scans with measurements of sulcal and ventricular volume, and measurements of regional CBF. All sedatives were withdrawn before CBF measurements were made. Before treatment, gray matter blood flow values were significantly reduced compared with those of age-matched normal volunteers, but white matter blood flow values were normal and the ventricles were enlarged. After abstinence from alcohol, mean gray matter blood flow values and brain volume both increased significantly.
20名有神经毒性体征但无韦尼克-科尔萨科夫综合征的重度慢性酒精中毒患者接受了戒酒治疗，并在之后定期进行前瞻性检查。系列检查包括详细的病史、神经系统检查、认知能力筛查检查、测量脑沟和脑室容积的计算机断层扫描以及局部脑血流量测量。在进行脑血流量测量之前停用所有镇静剂。治疗前，与年龄匹配的正常志愿者相比，灰质血流值显著降低，但白质血流值正常且脑室扩大。戒酒之后，灰质平均血流值和脑容量均显著增加。
