Bazargan Afsaneh Sadeghzadeh, Jafarzadeh Alireza, Ayoubi Ava, Roohaninasab Masoumeh, Dilmaghani Sara, Salehi Sepideh, Goodarzi Azadeh
Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine Iran University of Medical Sciences (IUMS) Tehran Iran.
Skin and Stem Cell Research Center Tehran University of Medical Sciences Tehran Iran.
Health Sci Rep. 2025 Apr 29;8(5):e70764. doi: 10.1002/hsr2.70764. eCollection 2025 May.
Androgenetic alopecia is the most common cause of hair loss in both men and women. The aim of this case-control study was to investigate the role of phenotype (hair shape, thickness, and color) and demographic characteristics, including smoking history, in the development of androgenetic alopecia.
In this case-control study, participants were divided into two groups: patients diagnosed with androgenetic alopecia (case group) and individuals without hair loss (control group). Data on demographic characteristics (age, gender), hair phenotype (shape, thickness, and color), and smoking history were collected. The case group consisted of individuals diagnosed with androgenetic alopecia at a skin and hair clinic, while the control group included patients visiting the clinic for other skin conditions. Data were analyzed using SPSS software.
The study compared data from 50 patients with androgenetic alopecia and 50 control participants. Smoking was found to increase susceptibility to alopecia, and a significant association was observed between lighter hair color and androgenetic alopecia. No significant relationship was found between hair thickness or shape and alopecia. Additionally, women had a higher prevalence of alopecia than men. Individuals with alopecia were significantly older, with a higher frequency of alopecia observed in those over the age of 25 (-value = 0.002).
Age, hair color, smoking, and gender were found to significantly influence the development of androgenetic alopecia. These findings suggest the importance of considering demographic and phenotypic factors in understanding the pathogenesis of this condition.
雄激素性脱发是男性和女性脱发的最常见原因。本病例对照研究的目的是调查表型(头发形状、粗细和颜色)以及包括吸烟史在内的人口统计学特征在雄激素性脱发发生中的作用。
在本病例对照研究中,参与者被分为两组:被诊断为雄激素性脱发的患者(病例组)和无脱发的个体(对照组)。收集了人口统计学特征(年龄、性别)、头发表型(形状、粗细和颜色)以及吸烟史的数据。病例组由在皮肤和毛发诊所被诊断为雄激素性脱发的个体组成,而对照组包括因其他皮肤疾病到诊所就诊的患者。使用SPSS软件对数据进行分析。
该研究比较了50例雄激素性脱发患者和50名对照参与者的数据。发现吸烟会增加患脱发的易感性,并且观察到头发颜色较浅与雄激素性脱发之间存在显著关联。未发现头发粗细或形状与脱发之间存在显著关系。此外,女性脱发的患病率高于男性。脱发患者的年龄明显更大,25岁以上人群中脱发的发生率更高(P值 = 0.002)。
发现年龄、头发颜色、吸烟和性别对雄激素性脱发的发生有显著影响。这些发现表明在理解这种疾病的发病机制时考虑人口统计学和表型因素的重要性。