Qin Deyu, Liu Guangxin, Zhang Jing, Lin Shanshan, Liu Xinmeng, Zhao Jingxiang, Zhang Qian, Ma Mei, Wang Shusen
The First Central Clinical School, Tianjin Medical University, Tianjin, 300070, People's Republic of China.
Department of Rehabilitation Medicine, Tianjin Chest Hospital, Tianjin, 300222, People's Republic of China.
Diabetes Metab Syndr Obes. 2025 Apr 24;18:1239-1254. doi: 10.2147/DMSO.S506870. eCollection 2025.
This study aimed to evaluate the effects of Adaptive Postural Balance Cardiac Rehabilitation Exercise (APBCRE) on glycolipid metabolism and exercise endurance in patients with coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM). Specifically, we compared the efficacy of APBCRE with aerobic exercise (AE) alone and irregular exercise (IE).
This randomized controlled trial included 348 patients with CAD, comprising 261 patients with T2DM and 87 non-diabetic CAD patients as a control group. Participants were randomly assigned to one of four groups: the APBCRE group, the AE group, the IE group, or the non-diabetic AE control group. The intervention lasted 8 weeks, including a structured 6-week training phase. Metabolic markers and exercise endurance were assessed at baseline (week 1) and post-intervention (week 8). Cardiopulmonary exercise testing (CPET) was utilized to individualize exercise prescriptions and optimize intervention intensity.
The APBCRE group demonstrated significant improvements in fasting blood glucose (FBG) (-11.34%, from 7.89 to 6.99 mmol/L, p < 0.05), HbA1c (-8.87%, from 7.20% to 6.56%, < 0.05), and LDL-C levels (-12.21%, from 2.44 to 2.14 mmol/L, < 0.05) compared to the AE and IE groups. While both APBCRE and AE improved lipid profiles, APBCRE demonstrated superior enhancements in exercise endurance, with max increasing by 18.71% (from 14.19 to 16.86 mL/min/kg, < 0.05) and AT increasing by 16.00% (from 11.62 to 13.48 mL/min/kg, < 0.05).
These findings support the efficacy of APBCRE in improving glycolipid metabolism, exercise endurance, and neuromuscular coordination in patients with CAD and T2DM compared to AE alone.
本研究旨在评估适应性姿势平衡心脏康复运动(APBCRE)对冠状动脉疾病(CAD)合并2型糖尿病(T2DM)患者糖脂代谢及运动耐力的影响。具体而言,我们比较了APBCRE与单纯有氧运动(AE)及非规律运动(IE)的疗效。
这项随机对照试验纳入了348例CAD患者,其中包括261例T2DM患者和87例非糖尿病CAD患者作为对照组。参与者被随机分配到四组之一:APBCRE组、AE组、IE组或非糖尿病AE对照组。干预持续8周,包括一个为期6周的结构化训练阶段。在基线(第1周)和干预后(第8周)评估代谢指标和运动耐力。采用心肺运动试验(CPET)来个体化运动处方并优化干预强度。
与AE组和IE组相比,APBCRE组的空腹血糖(FBG)显著改善(-11.34%,从7.89降至6.99 mmol/L,p<0.05),糖化血红蛋白(HbA1c)显著改善(-8.87%,从7.20%降至6.56%,p<0.05),低密度脂蛋白胆固醇(LDL-C)水平显著改善(-12.21%,从2.44降至2.14 mmol/L,p<0.05)。虽然APBCRE和AE均改善了血脂谱,但APBCRE在运动耐力方面表现出更优的提升,最大摄氧量(VO₂max)增加了18.71%(从14.19增至16.86 mL/min/kg,p<0.05),无氧阈(AT)增加了16.00%(从11.62增至13.48 mL/min/kg,p<0.05)。
这些发现支持了与单纯AE相比,APBCRE在改善CAD合并T2DM患者糖脂代谢、运动耐力及神经肌肉协调性方面的疗效。