Oliveira Natalia Pereira de, Pompei Luciano de Melo
School of Medicine of ABC, Santo André, SP, Brazil.
Climacteric. 2025 May 1:1-5. doi: 10.1080/13697137.2025.2486051.
Postmenopausal hypoestrogenism may cause significant changes in the oral cavity, interfering with inflammatory mechanisms such as salivary secretion. This study aimed to compare the salivary flow, pH levels and prevalence of dry mouth in postmenopausal women treated with hormone replacement therapy (HRT), those treated with selective serotonin reuptake inhibitors (SSRIs) and those without treatment.
Ninety postmenopausal women participated in the study. Of these, 30 used HRT, 30 used SSRIs and 30 did not receive any treatment (control). Salivary flow was measured using stimulated sialometry, while the pH level was measured using pH strips. Meanwhile, a questionnaire was used to assess for xerostomia.
The salivary flow measurements were 1.66 ± 0.49 ml/min for the HRT group, 1.23 ± 0.50 ml/min for the SSRI group and 1.68 ± 0.65 ml/min for the control group ( = 0.005 for comparison). The pH values were 7.13 ± 0.43, 7.0 ± 0.26 and 6.97 ± 0.41 for the HRT, SSRI and control groups, respectively. Xerostomia was reported in 60% of women receiving HRT, 46.7% receiving SSRIs and 26.7% of the controls ( = 0.033).
Women using SSRIs had lower salivary flow than the HRT or control group. However, xerostomia was more prevalent in women receiving HRT.
绝经后雌激素缺乏可能会导致口腔出现显著变化，干扰诸如唾液分泌等炎症机制。本研究旨在比较接受激素替代疗法（HRT）的绝经后女性、接受选择性5-羟色胺再摄取抑制剂（SSRIs）治疗的绝经后女性以及未接受治疗的绝经后女性的唾液流量、pH值水平和口干患病率。
90名绝经后女性参与了本研究。其中，30人使用HRT，30人使用SSRIs，30人未接受任何治疗（对照组）。使用刺激唾液分泌测量法测量唾液流量，同时使用pH试纸测量pH值水平。此外，使用一份问卷评估口干情况。
HRT组的唾液流量测量值为1.66±0.49毫升/分钟，SSRI组为1.23±0.50毫升/分钟，对照组为1.68±0.65毫升/分钟（比较时P = 0.005）。HRT组、SSRI组和对照组的pH值分别为7.13±0.43、7.0±0.26和6.97±0.41。报告有口干症状的女性在接受HRT的人群中占60%，接受SSRIs治疗的人群中占46.7%，对照组中占26.7%（P = 0.033）。
使用SSRIs的女性唾液流量低于HRT组或对照组。然而，口干在接受HRT的女性中更为普遍。
