Le Jingqi, Deng Wangyan, Le Tao
School of General Education and International Studie, Chongqing Polytechnic University of Electronic Technology, Chongqing 401331, China.
College of Life Sciences, Chongqing Normal University, Chongqing 401331, China.
Brain Sci. 2025 Mar 25;15(4):338. doi: 10.3390/brainsci15040338.
: Depression is a common mental disorder, and traditional treatments are often associated with side effects, making it particularly important to identify safe and effective alternative therapies. As a non-invasive intervention, music therapy has attracted increasing attention in the field of mental health in recent years. : This study aimed to explore the effectiveness of music interventions in alleviating depressive symptoms through a systematic review of their effects on a rat model of depression. The databases PubMed, Embase, Medline, PsycINFO, Scopus, Web of Science, the Cochrane Library, Google Scholar, and Ovid MEDLINE were searched for publications dated between January 2010 and November 2024. : First, the construction methods and behavioral test approaches used in depressive rat models were introduced and analyzed. Second, the effects of music on the physiological and biochemical indexes, as well as the neural structure and function of depressed rats, were discussed. The types of music influencing depressive behaviors in rats were also summarized and discussed. Finally, current concerns and challenges in translating music therapy into clinical applications for depression were reviewed, alongside future prospects for its development. : It is anticipated that this review will pave the way for both basic research and the clinical application of music therapy in the treatment of depression.
抑郁症是一种常见的精神障碍，传统治疗方法往往伴有副作用，因此确定安全有效的替代疗法尤为重要。作为一种非侵入性干预措施，音乐疗法近年来在心理健康领域受到越来越多的关注。本研究旨在通过系统综述音乐干预对抑郁症大鼠模型的影响，探讨其在缓解抑郁症状方面的有效性。检索了PubMed、Embase、Medline、PsycINFO、Scopus、Web of Science、Cochrane图书馆、谷歌学术和Ovid MEDLINE等数据库，查找2010年1月至2024年11月期间发表的文献。首先，介绍并分析了抑郁症大鼠模型的构建方法和行为测试方法。其次，讨论了音乐对抑郁症大鼠生理生化指标以及神经结构和功能的影响。还总结并讨论了影响大鼠抑郁行为的音乐类型。最后，综述了将音乐疗法转化为抑郁症临床应用的当前关注点和挑战，以及其未来发展前景。预计本综述将为音乐疗法治疗抑郁症的基础研究和临床应用铺平道路。
