Bauer Isabelle E, Frazier Thomas W, Meyer Thomas D, Youngstrom Eric, Zunta-Soares Giovana B, Soares Jair C
1 Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston , Houston, Texas.
2 Cleveland Clinic, Pediatric Institute , Cleveland, Ohio.
J Child Adolesc Psychopharmacol. 2015 Nov;25(9):684-90. doi: 10.1089/cap.2015.0076. Epub 2015 Oct 15.
Bipolar disorder (BD) is characterized by biased processing of emotional information. However, little research in this area has been conducted in youth with BD and at-risk individuals. The goal of this study was to determine whether children with BD displayed comparable or more severe manifestations of this bias relative to offspring of parents with BD.
The sample (n = 57 children and adolescents) included 18 individuals with BD (age: 13.63 ± 2.99; 8 females), 16 offspring of parents with BD (age: 11.83 ± 2.96; 9 females) and 23 healthy controls (HC) (age: 12.789 ± 3.087; 8 females). All participants performed the Affective Go/No-Go (AGN) and the Rapid Visual Processing (RVP) tasks of the Cambridge Neuropsychological Test Automated Battery (CANTAB).
Relative to HC, individuals with BD responded faster to correct trials and committed an elevated number of commission errors across all affective conditions of the AGN task. By contrast, BD offspring showed intact performance accuracy but quicker response times than HC. Post-hoc analyses revealed that this behavioral pattern was observed in BD offspring with mental health problems but not in healthy BD offspring. Overall, mean reaction times and total number of errors in the RVP task were comparable across groups.
In line with previous findings, subjects with BD encountered difficulties in processing affective information. The tendency toward faster but accurate responses to affective stimuli observed in BD offspring may be a marker of attentional bias toward affective information and constitute a vulnerability marker for mood disorder.
双相情感障碍（BD）的特征是对情绪信息的加工存在偏差。然而，该领域针对双相情感障碍青少年及高危个体的研究较少。本研究的目的是确定双相情感障碍儿童相对于双相情感障碍患者的后代，是否表现出类似或更严重的这种偏差表现。
样本（n = 57名儿童和青少年）包括18名双相情感障碍患者（年龄：13.63 ± 2.99；8名女性）、16名双相情感障碍患者的后代（年龄：11.83 ± 2.96；9名女性）和23名健康对照者（HC）（年龄：12.789 ± 3.087；8名女性）。所有参与者均完成了剑桥神经心理测试自动成套系统（CANTAB）的情感Go/No-Go（AGN）任务和快速视觉处理（RVP）任务。
相对于健康对照者，双相情感障碍患者在AGN任务的所有情感条件下，对正确试验的反应更快，且犯的误判错误数量更多。相比之下，双相情感障碍患者的后代表现出完整的表现准确性，但反应时间比健康对照者更快。事后分析显示，这种行为模式在有心理健康问题的双相情感障碍患者后代中观察到，但在健康的双相情感障碍患者后代中未观察到。总体而言，RVP任务中的平均反应时间和错误总数在各组之间相当。
与先前的研究结果一致，双相情感障碍患者在处理情感信息方面存在困难。在双相情感障碍患者后代中观察到的对情感刺激更快但准确的反应倾向，可能是对情感信息注意力偏差的一个标志，并构成情绪障碍的一个易感性标志。
