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膳食纤维在儿科患者血脂异常治疗中的应用

Fiber in the Treatment of Dyslipidemia in Pediatric Patients.

作者信息

Capra Maria Elena, Biasucci Giacomo, Travaglia Elisa, Sodero Roberta, Banderali Giuseppe, Pederiva Cristina

机构信息

Pediatrics and Neonatology Unit, Guglielmo da Saliceto Hospital, 29121 Piacenza, Italy.

Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy.

出版信息

Children (Basel). 2025 Mar 28;12(4):427. doi: 10.3390/children12040427.

DOI:10.3390/children12040427
PMID:40310063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12025725/
Abstract

Dietary fiber is present in many food categories (fruits, cereals, vegetables, legumes), and is considered a beneficial component of adult and children's diets. It is now well-established that dietary intervention is the first line of treatment for childhood dyslipidemia, both as a curative intervention (Familial Hyperchylomicronemia Syndrome, Sitosterolemia) and as an appropriate lifestyle aimed at improving the lipid profile in dyslipidemia, which is associated with early atherosclerosis and an increased risk of cardiovascular disease in adulthood (Familial Hypercholesterolemia, overweight- and obesity-related dyslipidemia). In this paper, we reviewed the main consensus documents to determine the current indications for its use in children and adolescents, and analyzed the few specific papers on the subject in the literature to assess how fiber is currently used in the treatment of pediatric dyslipidemia, what precautions should be taken, and what the main benefits of fiber are on the lipid profile and cardiovascular risk.

摘要

膳食纤维存在于许多食物类别中(水果、谷物、蔬菜、豆类),并被认为是成人和儿童饮食中的有益成分。现在已经明确,饮食干预是儿童血脂异常的一线治疗方法,既作为一种治疗性干预措施(家族性高乳糜微粒血症综合征、谷甾醇血症),也作为一种旨在改善血脂异常患者血脂状况的适当生活方式,血脂异常与早期动脉粥样硬化以及成年期心血管疾病风险增加相关(家族性高胆固醇血症、超重和肥胖相关血脂异常)。在本文中,我们回顾了主要的共识文件,以确定其在儿童和青少年中使用的当前适应证,并分析了文献中关于该主题的少数特定论文,以评估目前纤维在小儿血脂异常治疗中的使用方式、应采取哪些预防措施以及纤维对血脂状况和心血管风险的主要益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89e6/12025725/b60aa0a8b415/children-12-00427-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89e6/12025725/b60aa0a8b415/children-12-00427-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89e6/12025725/b60aa0a8b415/children-12-00427-g001.jpg

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本文引用的文献

1
Cholesterol-Lowering Bioactive Foods and Nutraceuticals in Pediatrics: Clinical Evidence of Efficacy and Safety.儿科降脂生物活性食品和营养保健品:疗效和安全性的临床证据。
Nutrients. 2024 May 18;16(10):1526. doi: 10.3390/nu16101526.
2
Total dietary fiber intake is inversely associated with metabolically unhealthy status in adolescents with excess weight.在超重青少年中,膳食纤维总摄入量与代谢不健康状态呈负相关。
Nutr Res. 2024 May;125:69-78. doi: 10.1016/j.nutres.2024.02.009. Epub 2024 Feb 29.
3
Long-term clinical outcomes and management of hypertriglyceridemia in children with Apo-CII deficiency.
载脂蛋白 CII 缺乏症患儿的高甘油三酯血症的长期临床结局和管理。
Nutr Metab Cardiovasc Dis. 2024 Jul;34(7):1798-1806. doi: 10.1016/j.numecd.2024.02.006. Epub 2024 Feb 17.
4
Association between adherence to the EAT-Lancet sustainable reference diet and cardiovascular health among European adolescents: the HELENA study.欧洲青少年对《柳叶刀-饮食与健康》可持续参考饮食的依从性与心血管健康之间的关联:HELENA研究
Eur J Clin Nutr. 2024 Mar;78(3):202-208. doi: 10.1038/s41430-023-01379-4. Epub 2023 Dec 13.
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Clinical profile, genetic spectrum and therapy evaluation of 19 Chinese pediatric patients with lipoprotein lipase deficiency.19例中国儿童脂蛋白脂肪酶缺乏症患者的临床特征、基因谱及治疗评估
J Clin Lipidol. 2023 Nov-Dec;17(6):808-817. doi: 10.1016/j.jacl.2023.09.012. Epub 2023 Sep 27.
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Dietary Models and Cardiovascular Risk Prevention in Pediatric Patients.饮食模式与儿科患者心血管风险预防
Nutrients. 2023 Aug 21;15(16):3664. doi: 10.3390/nu15163664.
7
Long-Term Treatment of Lipoprotein Lipase Deficiency with Medium-Chain Triglyceride-Enriched Diet: A Case Series.脂蛋白脂肪酶缺乏症的长程中链甘油三酯饮食治疗:病例系列。
Nutrients. 2023 Aug 11;15(16):3535. doi: 10.3390/nu15163535.
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Dietary intervention for children and adolescents with familial hypercholesterolaemia.家族性高胆固醇血症患儿和青少年的饮食干预。
Ital J Pediatr. 2023 Jun 22;49(1):77. doi: 10.1186/s13052-023-01479-8.
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Nutritional Treatment of Hypertriglyceridemia in Childhood: From Healthy-Heart Counselling to Life-Saving Diet.儿童高甘油三酯血症的营养治疗:从心脏健康咨询到救命饮食。
Nutrients. 2023 Feb 22;15(5):1088. doi: 10.3390/nu15051088.
10
Soluble Fiber Supplementation and Serum Lipid Profile: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.可溶性纤维补充剂与血清脂质谱:随机对照试验的系统评价和剂量反应荟萃分析。
Adv Nutr. 2023 May;14(3):465-474. doi: 10.1016/j.advnut.2023.01.005. Epub 2023 Feb 2.