• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

产妇脊髓麻醉对新生儿结局的影响：临床视角

The Impact of Maternal Spinal Anesthesia on Newborn Out-Comes: A Clinical Perspective.

作者信息

Moisa Ramona Celia, Negrut Nicoleta, Macovei Iulia Codruta, Aur Cristina, Botea Mihai Octavian, Maghiar Paula Bianca, Moisa Cezar Cristian Mihai, John Harrie Toms, Marian Paula

机构信息

Clinic of Anaesthesia and Intensive Care, Pelican Clinic, Medicover Hospital, 4104869 Oradea, Romania.

Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.

出版信息

Children (Basel). 2025 Mar 31;12(4):450. doi: 10.3390/children12040450.

DOI:10.3390/children12040450
PMID:40310089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12026138/
Abstract

BACKGROUND/OBJECTIVES: Spinal anesthesia, frequently used in cesarean deliveries, can have a significant impact on newborns. This study aims to evaluate the effects of spinal anesthesia with morphine or fentanyl as adjuvants on neonatal outcomes.

METHODS

A retrospective study was conducted over a specific period on 170 newborns delivered via cesarean section at the Pelican Clinic, Medicover Hospital, Romania. The neonatal parameters assessed included Apgar scores at 1 and 5 min, oxygen saturation, respiratory rate, and heart rate in two groups of newborns whose mothers underwent spinal anesthesia with bupivacaine combined with either morphine or fentanyl (group M_n and group F_n). Statistical analysis was performed using IBM SPSS Statistics (version 29.0.2.0 (20)).

RESULTS

Newborns in the M_n group had significantly higher Apgar scores at 1 min compared to those in the F_n group (9.63 ± 0.57 vs 9.40 ± 0.65, = 0.010); however, at 5 min, the scores were comparable between groups. Regarding oxygen saturation, male neonates born to mothers who received morphine had significantly higher values than those in the fentanyl group (96.08 ± 4.14% vs. 94.50 ± 4.36%, = 0.026), whereas no significant differences were observed in female neonates.

CONCLUSIONS

The use of morphine in maternal spinal anesthesia may improve immediate neonatal adaptation, particularly in male newborns.

摘要

背景/目的：剖宫产中常用的脊髓麻醉会对新生儿产生重大影响。本研究旨在评估以吗啡或芬太尼作为佐剂的脊髓麻醉对新生儿结局的影响。

方法

对罗马尼亚梅迪科弗医院鹈鹕诊所170例剖宫产分娩的新生儿进行了为期特定时间段的回顾性研究。评估的新生儿参数包括两组新生儿的1分钟和5分钟阿氏评分、血氧饱和度、呼吸频率和心率，这两组新生儿的母亲接受了布比卡因联合吗啡或芬太尼的脊髓麻醉（M_n组和F_n组）。使用IBM SPSS Statistics（版本29.0.2.0（20））进行统计分析。

结果

M_n组新生儿1分钟时的阿氏评分显著高于F_n组（9.63±0.57 vs 9.40±0.65，P = 0.010）；然而，5分钟时，两组评分相当。关于血氧饱和度，接受吗啡的母亲所生的男婴的值显著高于芬太尼组（96.08±4.14% vs. 94.50±4.36%，P = 0.026），而女婴未观察到显著差异。

结论

母亲脊髓麻醉中使用吗啡可能会改善新生儿的即刻适应性，尤其是男婴。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/12026138/36a7c55f3fe6/children-12-00450-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/12026138/3b125f7ff121/children-12-00450-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/12026138/a2675d7e197b/children-12-00450-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/12026138/055c464e1ba1/children-12-00450-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/12026138/4bf3fce0d172/children-12-00450-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/12026138/36a7c55f3fe6/children-12-00450-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/12026138/3b125f7ff121/children-12-00450-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/12026138/a2675d7e197b/children-12-00450-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/12026138/055c464e1ba1/children-12-00450-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/12026138/4bf3fce0d172/children-12-00450-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/12026138/36a7c55f3fe6/children-12-00450-g005.jpg

相似文献

1
The Impact of Maternal Spinal Anesthesia on Newborn Out-Comes: A Clinical Perspective.产妇脊髓麻醉对新生儿结局的影响：临床视角
Children (Basel). 2025 Mar 31;12(4):450. doi: 10.3390/children12040450.
2
[Addition of fentanyl to bupivacaine--peridural analgesia in cesarean section].[在布比卡因中添加芬太尼——剖宫产术中的硬膜外镇痛]
Anaesthesist. 1996 Jul;45(7):635-42. doi: 10.1007/s001010050297.
3
The effects of morphine and fentanyl alone or in combination added to intrathecal bupivacaine in spinal anesthesia for cesarean section.在剖宫产脊髓麻醉中，单独使用吗啡和芬太尼或二者联合添加到鞘内布比卡因中的效果。
Agri. 2011 Apr;23(2):57-63.
4
Effects on newborns of applying bupivacaine combined with different doses of fentanyl for cesarean section.布比卡因联合不同剂量芬太尼用于剖宫产对新生儿的影响。
World J Clin Cases. 2021 Aug 16;9(23):6698-6704. doi: 10.12998/wjcc.v9.i23.6698.
5
Cerebral Oxygenation in Neonates Immediately after Cesarean Section and Mode of Maternal Anesthesia.剖宫产术后新生儿脑氧合与母亲麻醉方式。
Neonatology. 2019;116(2):132-139. doi: 10.1159/000499046. Epub 2019 May 16.
6
Prospective, randomized trial comparing general with spinal anesthesia for cesarean delivery in preeclamptic patients with a nonreassuring fetal heart trace.一项前瞻性随机试验，比较全身麻醉与脊髓麻醉用于胎儿心率异常的子痫前期患者剖宫产的效果。
Anesthesiology. 2003 Sep;99(3):561-9; discussion 5A-6A. doi: 10.1097/00000542-200309000-00010.
7
A single dose of fentanyl and midazolam prior to Cesarean section have no adverse neonatal effects.剖宫产术前单次注射芬太尼和咪达唑仑对新生儿无不良影响。
Can J Anaesth. 2006 Jan;53(1):79-85. doi: 10.1007/BF03021531.
8
The Impact of Fentanyl and Morphine on Maternal Hemodynamics in Spinal Anesthesia for Cesarean Section.芬太尼和吗啡对剖宫产脊髓麻醉中产妇血流动力学的影响。
Pharmaceuticals (Basel). 2025 Mar 11;18(3):392. doi: 10.3390/ph18030392.
9
Addition of Fentanyl or High-Dose Morphine to Bupivacaine Is Superior to Bupivacaine Alone during Single-Shot Spinal Anesthesia.布比卡因中添加芬太尼或高剂量吗啡优于单独使用布比卡因行单次蛛网膜下腔麻醉。
Gynecol Obstet Invest. 2020;85(4):312-317. doi: 10.1159/000509513. Epub 2020 Aug 11.
10
An Observational Study on Arrhythmia During Cesarean Section Under Spinal Anesthesia: Incidence, Risk Factors, and Effects on Immediate Post-delivery Neonatal Outcome.腰麻下剖宫产术中心律失常的观察性研究：发生率、危险因素及其对产后即刻新生儿结局的影响
Cureus. 2021 Aug 5;13(8):e16898. doi: 10.7759/cureus.16898. eCollection 2021 Aug.

本文引用的文献

1
The Impact of Fentanyl and Morphine on Maternal Hemodynamics in Spinal Anesthesia for Cesarean Section.芬太尼和吗啡对剖宫产脊髓麻醉中产妇血流动力学的影响。
Pharmaceuticals (Basel). 2025 Mar 11;18(3):392. doi: 10.3390/ph18030392.
2
Optimizing Newborn Outcomes in Cesarean Sections: A Comparative Analysis of Stress Indicators under General and Spinal Anesthesia.优化剖宫产新生儿结局：全身麻醉与脊髓麻醉下应激指标的比较分析
Children (Basel). 2024 Jun 27;11(7):783. doi: 10.3390/children11070783.
3
Effect of anesthesia administration method on apgar scores of infants born to women undergoing elective cesarean section.
麻醉给药方式对择期剖宫产产妇所娩婴儿阿普加评分的影响。
BMC Anesthesiol. 2023 Apr 27;23(1):142. doi: 10.1186/s12871-023-02098-w.
4
Total failure of spinal anesthesia for cesarean delivery, associated factors, and outcomes: A retrospective case-control study.剖宫产术脊麻完全失败的相关因素及结局：一项回顾性病例对照研究。
Medicine (Baltimore). 2022 Jul 8;101(27):e29813. doi: 10.1097/MD.0000000000029813.
5
In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats.在体药代动力学分析三种不同理化性质药物在妊娠大鼠胎盘转运中的应用。
Reprod Toxicol. 2022 Aug;111:194-203. doi: 10.1016/j.reprotox.2022.06.007. Epub 2022 Jun 15.
6
Impact of interval between induction of spinal anesthesia to delivery on umbilical arterial cord ph of neonates delivered by elective cesarean section.椎管内麻醉诱导至剖宫产分娩时间间隔对择期剖宫产新生儿脐动脉血 pH 值的影响。
BMC Pregnancy Childbirth. 2022 Mar 17;22(1):216. doi: 10.1186/s12884-022-04536-y.
7
Techniques for preventing hypotension during spinal anaesthesia for caesarean section.剖宫产脊髓麻醉期间预防低血压的技术。
Cochrane Database Syst Rev. 2017 Aug 4;8(8):CD002251. doi: 10.1002/14651858.CD002251.pub3.
8
Effects of Intrathecal Opioids Use in Cesarean Section on Breastfeeding and Newborns' Weight Gaining.剖宫产术中鞘内使用阿片类药物对母乳喂养及新生儿体重增加的影响
J Family Reprod Health. 2016 Dec;10(4):176-183.
9
Sudden persistent fetal bradycardia after spinal analgesia for labor pain.分娩镇痛脊髓镇痛后突发持续性胎儿心动过缓。
Korean J Anesthesiol. 2013 Dec;65(6 Suppl):S99-S100. doi: 10.4097/kjae.2013.65.6S.S99.
10
A comparison of intrathecal dexmedetomidine, clonidine, and fentanyl as adjuvants to hyperbaric bupivacaine for lower limb surgery: A double blind controlled study.鞘内注射右美托咪定、可乐定和芬太尼作为下肢手术中高压布比卡因辅助剂的比较：一项双盲对照研究。
J Anaesthesiol Clin Pharmacol. 2013 Oct;29(4):496-502. doi: 10.4103/0970-9185.119151.