Elferink Marloes A G, Galanos Laskarina J K, Sijtsma Femke P C, Bijlsma Maarten J, Buffart Tineke E, de Hingh Ignace H J T, van Leerdam Monique E, van Erning Felice N
Integraal Kankercentrum Nederland, afd. Research & Development, Utrecht.
Contact:
Ned Tijdschr Geneeskd. 2025 Apr 24;169:D8459.
To describe trends in incidence of early-onset colorectal cancer in the Netherlands.
Observational research.
We selected colorectal cancer patients aged 15 to 49 years, diagnosed between 1989-2023, from the Netherlands Cancer Registry (NCR). We calculated incidence rates and determined changes in trends using Joinpoint regression analyses. Furthermore, we made a prediction of the number of early-onset colorectal cancer patients in 2035.
The number of new early-onset colorectal cancer patients has increased; from 6.3 per 100,000 in 1998 to 9.3 per 100,000 in 2023 (Annual Percentage Change 1.41% (95% confidence interval 1.18-1.71)). This incidence is expected to increase further in the future, reaching between 629 and 871 cases by 2035.
There is an increase in the incidence of early-onset colorectal cancer in the Netherlands which appears to persist over the next 10 years. Further research is needed to identify the causes of this increase.
描述荷兰早发性结直肠癌的发病率趋势。
观察性研究。
我们从荷兰癌症登记处（NCR）选取了1989年至2023年间诊断出的15至49岁的结直肠癌患者。我们计算了发病率，并使用Joinpoint回归分析确定趋势变化。此外，我们还对2035年早发性结直肠癌患者的数量进行了预测。
新的早发性结直肠癌患者数量有所增加；从1998年的每10万人6.3例增至2023年的每10万人9.3例（年变化率1.41%（95%置信区间1.18 - 1.71））。预计未来这一发病率还会进一步上升，到2035年将达到629至871例。
荷兰早发性结直肠癌的发病率有所上升，且在未来10年似乎会持续。需要进一步研究以确定这种上升的原因。
