Al-Maghrabi Haneen, Al-Maghrabi Jaudah
Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Jeddah 23433, Saudi Arabia.
Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah 23433, Saudi Arabia.
Diagnostics (Basel). 2025 Apr 16;15(8):1016. doi: 10.3390/diagnostics15081016.
Diagnoses of primary gynecologic (GYN) lymphomas are rare and require a high clinical index of suspicion, with only case reports and case series being presented. The aim of this study is to assess and record the pathological distinction of primary GYN lymphomas at two tertiary hospitals. We retrieved all cases diagnosed from 2000 to 2024, reviewed histopathology slides, and performed additional extra immunohistochemistry staining for required cases. In addition, follow-up information available up to the point of writing this study was gathered. The records of two hospitals indicated 15 instances of primary GYN lymphoma in patients aged between 18 and 79. Only one patient was human immunodeficiency virus (HIV)-positive. Symptoms in most cases were non-specific, and most of the patients presented with the primary complaint of unexplained bleeding. A total of 13 cases were classified as diffuse large B-cell lymphoma (DLBCL), 1 as acute B-lymphoblastic lymphoma (B-LBL), and 1 as Burkitt lymphoma (BL). Primary lymphoma of the GYN tract is a rare disease, with DLBCL being the most prevalent type in our area. Our review, based on experiences from two large tertiary centers in the western region of Saudi Arabia, aims to contribute to this effort. The reporting of additional cases of primary GYN lymphoma is needed, which may aid in a better understanding of its pathogenesis as well as enhancing diagnosis and treatment outcomes.
原发性妇科淋巴瘤的诊断较为罕见，需要高度的临床怀疑指数，目前仅有病例报告和病例系列发表。本研究的目的是评估并记录两家三级医院原发性妇科淋巴瘤的病理特征。我们检索了2000年至2024年期间诊断的所有病例，复查了组织病理学切片，并对必要病例进行了额外的免疫组化染色。此外，收集了截至撰写本研究时可获得的随访信息。两家医院的记录显示，15例原发性妇科淋巴瘤患者年龄在18至79岁之间。只有1例患者为人类免疫缺陷病毒（HIV）阳性。大多数病例的症状不具有特异性，大多数患者的主要诉求是不明原因的出血。共有13例被分类为弥漫性大B细胞淋巴瘤（DLBCL），1例为急性B淋巴细胞白血病（B-LBL），1例为伯基特淋巴瘤（BL）。原发性妇科淋巴瘤是一种罕见疾病，DLBCL是我们地区最常见的类型。我们基于沙特阿拉伯西部地区两家大型三级中心的经验进行的综述旨在为此做出贡献。需要报告更多原发性妇科淋巴瘤病例，这可能有助于更好地理解其发病机制，并改善诊断和治疗结果。
