Chan John K, Loizzi Vera, Magistris Alessandra, Hunter Mark I, Rutgers Joanne, DiSaia Philip J, Berman Michael L
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA, USA.
Am J Obstet Gynecol. 2005 Sep;193(3 Pt 1):866-72. doi: 10.1016/j.ajog.2005.04.044.
Primary lymphoma of the uterine cervix is rare, with less than 60 cases reported. We present a series of 6 patients with cervical lymphoma and review the literature.
Between 1988 and 2003, we identified 6 women with primary lymphoma of the uterine cervix treated at our institutions. Data for analysis were obtained from hospital charts, office records, and tumor registry files. We also reviewed 20 published reports on cervical lymphoma, providing information on 58 additional patients.
The median age at diagnosis was 52 years (range 40-76). Three patients had an abnormal Papanicolaou test within 6 months of the diagnosis. Mean tumor size was 8.3 cm (range 3-14 cm). On the basis of the Ann Arbor system of staging where "E" denotes extranodal tumor origin, 2 patients had stage IE, 1 had stage IIIE, and 3 had stage IVE disease. The median follow-up for these 6 women was 33 months (range 12-120). Adding the 6 patients in our series to the 58 patients obtained from published reports, 43 had stage IE, 14 had stage IIE, 2 had stage IIIE, and 5 had stage IVE disease. There was no consistent pattern of treatment identified from our literature review.
Primary lymphoma of the uterine cervix is a rare malignancy. Most patients present with stage IE disease. Women with localized disease typically respond to various combinations of surgery, chemotherapy, and radiotherapy. Combination chemotherapy with tailored radiotherapy appears to be the preferred treatment option in women with advanced disease.
宫颈原发性淋巴瘤罕见，报道病例不足60例。我们报告6例宫颈淋巴瘤患者并复习相关文献。
1988年至2003年间，我们确定了在本机构接受治疗的6例宫颈原发性淋巴瘤女性患者。分析数据来自医院病历、门诊记录和肿瘤登记档案。我们还复习了20篇关于宫颈淋巴瘤的已发表报告，提供了另外58例患者的信息。
诊断时的中位年龄为52岁（范围40 - 76岁）。3例患者在诊断后6个月内巴氏试验异常。平均肿瘤大小为8.3厘米（范围3 - 14厘米）。根据Ann Arbor分期系统，其中“E”表示结外肿瘤起源，2例为IE期，1例为IIIE期，3例为IVE期疾病。这6名女性的中位随访时间为33个月（范围12 - 120个月）。将我们系列中的6例患者与从已发表报告中获得的58例患者相加，43例为IE期，14例为IIE期，2例为IIIE期，5例为IVE期疾病。我们的文献复习未发现一致的治疗模式。
宫颈原发性淋巴瘤是一种罕见的恶性肿瘤。大多数患者表现为IE期疾病。局限性疾病的女性通常对手术、化疗和放疗的各种组合有反应。联合化疗加定制放疗似乎是晚期疾病女性的首选治疗方案。
