Schwarz J A
Immun Infekt. 1977 Feb;5(1):23-9.
7S-IgM is the first specific antibody during evolution of vertebrates. The detection of monomeric IgM in monoclonal grammopathies, autoimmune and infectious diseases is believed to be an atavistic primary IgM response in cases of elevated humoral immune reactions and disorders of lymphatic tissues.
7S-IgM是脊椎动物进化过程中出现的第一种特异性抗体。在单克隆丙种球蛋白病、自身免疫性疾病和感染性疾病中检测到单体IgM,被认为是在体液免疫反应增强和淋巴组织紊乱情况下的一种返祖性原始IgM反应。