Chen Hui-Mei, Huang Chien-Sheng, Wu Yu-Chung, Chien Ling-I, Hsu Po-Kuei
School of Nursing, College of Nursing, National Taipei University of Nursing and Health Sciences, Mingde Rd, Office S307, No. 365, Beitou District, Taipei City, 112303, Taiwan.
Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei City, 112303, Taiwan.
Support Care Cancer. 2025 May 1;33(5):441. doi: 10.1007/s00520-025-09489-4.
To examine the effects of a 12-week rehabilitation program of exercise combined with diet education on the quality of life (QOL) and symptoms (anxiety, depression, rest/activity circadian rhythm (RACR), and sleep) of patients with esophageal cancer.
We used a two-parallel-arms randomized controlled trial. The experimental group (EG) participated in a 12-week program involving walking exercise and diet education. The control group (CG) received standard care. The primary outcome was QOL, measured using the European Organisation for Research and Treatment of Cancer QOL core questionnaire (QLQ-C30) and esophageal module 18 (EORTC QLQ-OES18). Secondary outcomes were anxiety, depression, RACR, and sleep characteristics. Measurement time points were baseline and 3, 6, and 12 months after recruitment.
Of 85 enrolled patients with esophageal cancer (EG = 43, CG = 42), the majority were male, 59 years old on average, and had received surgery. The EG recorded significantly better 24-h autocorrelation coefficient (0.06 to 0.24, p = 0.002; Cohen's d = 0.98) of rest/activity rhythms parameters at 6 months. In the EG, total sleep time significantly increased at 3 months (16.36 to 86.07, p = 0.004; Cohen's d = 0.86).
The intervention improved the RACR and sleep of patients with esophageal cancer. Healthcare professionals may consider incorporating this rehabilitation program into routine care alongside cancer treatment for patients with esophageal cancer. TRIAL REGISTRATION: Clinicaltrials.gov (registration number: NCT03161535). Prospectively registered on 17 May 2017.
探讨为期12周的运动与饮食教育相结合的康复计划对食管癌患者生活质量（QOL）及症状（焦虑、抑郁、休息/活动昼夜节律（RACR）和睡眠）的影响。
我们采用双臂平行随机对照试验。实验组（EG）参加为期12周的包含步行运动和饮食教育的计划。对照组（CG）接受标准护理。主要结局为生活质量，采用欧洲癌症研究与治疗组织生活质量核心问卷（QLQ-C30）和食管模块18（EORTC QLQ-OES18）进行测量。次要结局为焦虑、抑郁、RACR和睡眠特征。测量时间点为基线以及招募后3、6和12个月。
在85例入组的食管癌患者中（EG = 43例，CG = 42例），大多数为男性，平均年龄59岁，且接受过手术。实验组在6个月时的休息/活动节律参数的24小时自相关系数显著更好（0.06至0.24，p = 0.002；Cohen's d = 0.98）。在实验组中，总睡眠时间在3个月时显著增加（16.36至86.07，p = 0.004；Cohen's d = 0.86）。
该干预改善了食管癌患者的RACR和睡眠。医疗保健专业人员可考虑将此康复计划纳入食管癌患者癌症治疗的常规护理中。试验注册：Clinicaltrials.gov（注册号：NCT03161535）。于2017年5月17日进行前瞻性注册。
