Shin Hye-Rim, Kim Sun-Young, Bae In-Hye, Hwang Inseong, Park Jin Hoo, Ok Soo-Min, Kim Young-Youn, Cho Young-Dan
Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.
Department of Conservative Dentistry, School of Dentistry and Dental Research Institute, Seoul National University and Seoul National University Dental Hospital, Seoul, Korea.
J Periodontal Implant Sci. 2025 Apr;55(2):127-138. doi: 10.5051/jpis.2401920096. Epub 2025 Feb 6.
The Korean Oral Biobank Network (KOBN) collects, stores, and provides oral samples for research. Quality control (QC) of biospecimens is necessary to ensure that they meet the basic prerequisites before being sent to researchers. This study presents the standard operating procedures (SOPs) for the QC of biospecimens.
QC methods using molecular genetic techniques according to sample types, including teeth, blood, oral soft tissue, oral tissue-derived cells, saliva, mouth rinse solution, dental plaque, and gingival crevicular fluid, are described in detail.
The KOBN established SOP for oral biospecimen QC and assessment methods.
To ensure a stable supply of high-quality biospecimens for researchers, regular QC checks should be carried out according to the SOP following the specifications of the Korea Biobank Network under the Korea Disease Control and Prevention Agency.
韩国口腔生物样本库网络（KOBN）收集、储存并提供口腔样本用于研究。生物样本的质量控制（QC）对于确保其在送交研究人员之前满足基本前提条件是必要的。本研究介绍了生物样本质量控制的标准操作程序（SOP）。
详细描述了根据样本类型（包括牙齿、血液、口腔软组织、口腔组织来源细胞、唾液、漱口液、牙菌斑和龈沟液）使用分子遗传学技术的质量控制方法。
KOBN建立了口腔生物样本质量控制和评估方法的SOP。
为确保为研究人员稳定供应高质量生物样本，应按照韩国疾病控制与预防机构下属韩国生物样本库网络的规范，根据SOP定期进行质量控制检查。
