Malviya Niharika, Cheung Tracy, Kim Joseph, Aibel Kelli, Okada Chihiro, Abraham Nitya
Albert Einstein College of Medicine, Bronx, New York, USA.
Department of Urology, Montefiore Medical Center, Bronx, New York, USA.
Neurourol Urodyn. 2025 Jun;44(5):1149-1155. doi: 10.1002/nau.70064. Epub 2025 May 2.
This study aims to explore the relationship between urinary incontinence (UI) and mortality in women, with a focus on the potential role of frailty and variations across UI subtypes.
We analyzed 8967 women aged 40 and above who were part of the National Health and Nutrition Examination Survey (NHANES). Kaplan-Meier survival curves and Cox regression analyses were performed to assess the relationship between urge UI (UUI), stress UI (SUI), other UI (OUI) and all-cause mortality. These models were adjusted for demographic variables and frailty scores.
Approximately 45.8% of participants reported UI in the past year. Initial analysis showed a significant association between UI and increased mortality risk (hazard ratio [HR] = 1.478, 95% confidence interval [CI] 1.317-1.657, p < 0.001), persisting after controlling for frailty (HR = 1.151, 95% CI 1.022-1.297, p = 0.021). However, after adjusting for frailty and demographic factors, this association became non-significant.
Women with UI exhibited a significantly increased risk of all-cause mortality, but this association did not hold after accounting for both key demographics and frailty.
本研究旨在探讨女性尿失禁（UI）与死亡率之间的关系，重点关注虚弱的潜在作用以及UI各亚型之间的差异。
我们分析了8967名年龄在40岁及以上的女性，她们是美国国家健康与营养检查调查（NHANES）的一部分。采用Kaplan-Meier生存曲线和Cox回归分析来评估急迫性尿失禁（UUI）、压力性尿失禁（SUI）、其他尿失禁（OUI）与全因死亡率之间的关系。这些模型对人口统计学变量和虚弱评分进行了调整。
在过去一年中，约45.8%的参与者报告有尿失禁。初步分析显示，尿失禁与死亡风险增加之间存在显著关联（风险比[HR]=1.478，95%置信区间[CI]1.317-1.657，p<0.001），在控制虚弱因素后该关联依然存在（HR=1.151，95%CI 1.022-1.297，p=0.021）。然而，在对虚弱和人口统计学因素进行调整后，这种关联变得不显著。
患有尿失禁的女性全因死亡风险显著增加，但在考虑关键人口统计学因素和虚弱因素后，这种关联不再成立。
