Ceruso Francesco Mattia, Leon Stephany Gabriela Zambrano, Fiorillo Luca, Cervino Gabriele, Cicciù Marco, Heboyan Artak, Pernice Francesco, Meloni Silvio, Tallarico Marco
Department of Dentistry "Fra G.B. Orsenigo" Ospedale San Pietro F.B.F, Rome, Italy.
Department of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, Italy.
Clin Med Insights Case Rep. 2025 Apr 29;18:11795476251333251. doi: 10.1177/11795476251333251. eCollection 2025.
Age-related macular degeneration (AMD) is a leading cause of significant vision impairment in individuals aged 50 and older, primarily impacting central vision. This study seeks to investigate potential associations between periodontal disease and age-related maculopathy in the analyzed clinical case. A male subject of 66 years old, with age-related degenerative maculopathy and severe periodontal disease, was evaluated and treated. After an initial phase of non-surgical causal periodontal therapy, the periodontal indices were re-evaluated. In addition, the extraction of hopeless teeth replaced by dental implants was performed. A retinal topography was used to assess possible regression of the pathology, and proper anti-VEGF therapy was administered. The results showed a regression of periodontal disease and an improvement of the degenerative maculopathy. These preliminary results, even if encouraging, should be supported by larger prospective trials.
年龄相关性黄斑变性（AMD）是50岁及以上人群严重视力损害的主要原因，主要影响中心视力。本研究旨在调查在分析的临床病例中牙周疾病与年龄相关性黄斑病变之间的潜在关联。对一名66岁患有年龄相关性退行性黄斑病变和严重牙周疾病的男性受试者进行了评估和治疗。在进行非手术因果性牙周治疗的初始阶段后，重新评估了牙周指数。此外，拔除了无法保留的牙齿并植入了牙种植体。使用视网膜地形图评估病变的可能消退情况，并给予适当的抗血管内皮生长因子（VEGF）治疗。结果显示牙周疾病有所消退，退行性黄斑病变有所改善。这些初步结果即使令人鼓舞，也需要更大规模的前瞻性试验加以佐证。
