School and Hospital of Stomatology, China Medical University, Shenyang, China.
Liaoning Province Key Laboratory of Oral Diseases, Shenyang, China.
Biomed Res Int. 2020 Sep 28;2020:4753645. doi: 10.1155/2020/4753645. eCollection 2020.
Epidemiological studies have shown a correlation between periodontal disease (PD) and age-related macular degeneration (AMD). However, the results have been inconsistent, and no relevant meta-analysis has been performed on this topic. Hence, we performed a meta-analysis to evaluate whether the two diseases are related. . The PubMed, Embase, Cochrane Library, and Web of Science databases were searched up to April 20, 2020, for related articles. Two authors independently conducted literature screening and data extraction and then used the Stata 15.1 software to calculate the relative risk (RRs) and 95% confidence intervals (CIs) to assess the association between PD and AMD.
A total of 5 observational studies involving 112,240 participants and 5,005 AMD patients were included. The results of meta-analysis using the random-effects model showed that the incidence of AMD in PD patients was 1.35 times that of non-PD patients; the difference was statistically significant (RR = 1.35, 95%CI = 1.07-1.70, = 0.011). Sensitivity analysis showed that the results were stable.
PD patients have a higher risk of AMD, but the causal relationship between PD and AMD has not been confirmed. Further research should be carried out to verify the exact relationship between the two.
流行病学研究表明，牙周病（PD）与年龄相关性黄斑变性（AMD）之间存在相关性。然而，结果并不一致，且尚未对此主题进行相关的荟萃分析。因此，我们进行了一项荟萃分析，以评估这两种疾病是否相关。我们检索了PubMed、Embase、Cochrane Library 和 Web of Science 数据库，截至 2020 年 4 月 20 日，以获取相关文献。两位作者独立进行文献筛选和数据提取，然后使用 Stata 15.1 软件计算相对风险（RRs）和 95%置信区间（CIs），以评估 PD 与 AMD 之间的关联。
共纳入 5 项观察性研究，涉及 112240 名参与者和 5005 名 AMD 患者。使用随机效应模型进行荟萃分析的结果表明，PD 患者发生 AMD 的风险是无 PD 患者的 1.35 倍；差异具有统计学意义（RR=1.35，95%CI=1.07-1.70， = 0.011）。敏感性分析表明结果稳定。
PD 患者发生 AMD 的风险较高，但 PD 与 AMD 之间的因果关系尚未得到证实。应进一步开展研究以验证两者之间的确切关系。
