Marugo M, Molinari F, Fazzuoli L, Parodi M C, Bernasconi D, Menozzi F, Giordano G
J Endocrinol Invest. 1985 Apr;8(2):117-9. doi: 10.1007/BF03350662.
The presence of estradiol (E) and progesterone (Pg) receptors (R) has been demonstrated also in normal and neoplastic tissues known to be hormone-independent and in particular in primitive colonic cancer, and, possibly, in healthy colonic mucosa. In this study endoscopic and surgical colonic mucosa specimens from 55 subjects were analyzed and divided as follows: 21 samples from healthy subjects, 12 normal mucosa samples from subjects affected with colonic cancer, 8 adenomatous polyps specimens, 5 samples from ulcerative colitis drawn on areas showing macroscopic lesions and 9 colonic cancer specimens. In the control group we have observed 6 cases positive for ER (28.6%) and 2 positive for PgR (14.3%). Six normal mucosa specimens from subjects affected with colonic cancer were found to be positive for ER (50%) and 2 for PgR (16.7%). Five colonic cancers resulted ER positive (55.5%) and 4 PgR positive (44.4%). Four polyps were ER positive (50%) and 3 PgR positive (37.5%); in this group only one subject showed positive binding in the surrounding normal tissue. These data confirm the presence of ER and PgR in colonic cancer and colonic adenomas (so-called precancerous disease); in these subjects the finding of steroid receptors also in normal mucosa suggests that the presence of steroid binding could be considered as a marker of a precancerous condition.
在已知不依赖激素的正常组织和肿瘤组织中，尤其是在原发性结肠癌中，甚至可能在健康的结肠黏膜中，已证实存在雌二醇（E）和孕酮（Pg）受体（R）。在本研究中，对55名受试者的内镜和手术获取的结肠黏膜标本进行了分析，并分为以下几类：21份来自健康受试者的样本、12份来自结肠癌患者的正常黏膜样本、8份腺瘤性息肉标本、5份取自溃疡性结肠炎有宏观病变区域的样本以及9份结肠癌标本。在对照组中，我们观察到6例雌激素受体（ER）阳性（28.6%），2例孕酮受体（PgR）阳性（14.3%）。发现6份来自结肠癌患者的正常黏膜标本ER阳性（50%），2份PgR阳性（16.7%）。5例结肠癌ER阳性（55.5%），4例PgR阳性（44.4%）。4例息肉ER阳性（50%），3例PgR阳性（37.5%）；在该组中只有1名受试者在周围正常组织中显示出阳性结合。这些数据证实了结肠癌和结肠腺瘤（所谓的癌前疾病）中存在ER和PgR；在这些受试者中，正常黏膜中也发现类固醇受体表明类固醇结合的存在可被视为癌前状态的一个标志物。
