King R J
Cancer. 1980 Dec 15;46(12 Suppl):2818-21. doi: 10.1002/1097-0142(19801215)46:12+<2818::aid-cncr2820461416>3.0.co;2-z.
Estradiol receptor (RE) and progesterone receptor (RP) contents of primary human breast tumors are markedly influenced by histologic grade of the tumor. As the tumor becomes more anaplastic, there is an increase in the proportion of RE negative, RP negative tumors at the expense of the RE positive, RP positive group. Evidence is presented to suggest that some RE positive, RP negative tumors from postmenopausal women lack RP because of estrogen deficiency. The inclusion of RP assays increases the clinical usefulness of receptor assays in predicting response to hormone therapy for the advanced disease. Preliminary evidence suggest that RE and RP assays on the primary tumor may indicate the hormone sensitivity of subsequent metastatic disease.
原发性人类乳腺肿瘤的雌二醇受体（RE）和孕酮受体（RP）含量受肿瘤组织学分级的显著影响。随着肿瘤间变程度增加，RE阴性、RP阴性肿瘤的比例上升，而RE阳性、RP阳性组的比例下降。有证据表明，绝经后女性的一些RE阳性、RP阴性肿瘤因雌激素缺乏而缺乏RP。RP检测的纳入提高了受体检测在预测晚期疾病激素治疗反应方面的临床实用性。初步证据表明，对原发性肿瘤进行RE和RP检测可能提示后续转移性疾病的激素敏感性。
