Lv Tingting, Fang Weilin, Si Junwen, Ji Xiang, Li Ziwei, Song Xin, Huang Jin, Weng Zhijun, Lv Jianwei
Department of Urology, Shanghai Pudong New Area Gongli Hospital, Shanghai, China.
Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Curr Urol. 2025 Mar;19(2):110-116. doi: 10.1097/CU9.0000000000000266. Epub 2025 Jan 21.
The aim of this study was to observe the clinical effectiveness of simultaneous electroacupuncture stimulation on the tibial nerve (TN) and ilioinguinal-iliohypogastric nerve (IIN/IHN) in the treatment of refractory overactive bladder (OAB) in women.
A prospective study was conducted involving 94 female patients with a diagnosis of OAB in the Urology Department of our hospital from September 2022 to October 2023. The patients were randomly divided into a TN-IIN/IHN group and a control group, each comprising 47 cases. All patients in both groups had received anticholinergic muscarinic receptor antagonists (tolterodine/solifenacin), β3 receptor agonists, flupentixol/melitracen, and other basic treatment regimens with poor results. The TN-IIN/IHN group received simultaneous electroacupuncture on the TN and IIN/IHN, whereas the control group received pelvic floor muscle biofeedback electrical stimulation. Both groups underwent treatment 3 times a week for a total of 4 weeks. Bladder symptoms (24-hour voiding diary), OAB Symptom Score, OAB-Quality of Life Questionnaire, and anxiety and depression scores were compared and analyzed before treatment, after treatment, and at a 3-month follow-up. Clinical efficacy was also assessed.
Both groups showed significant improvement in voiding frequency, nocturia, urgency, OAB Symptom Score, and average voiding volume after treatment and at follow-up ( < 0.01). The TN-IIN/IHN group showed significantly superior results compared with the control group ( < 0.01). Quality of life scores and anxiety and depression scores significantly decreased ( < 0.01), with the TN-IIN/IHN group scores significantly lower than those of the control group ( < 0.01). The treatment success rate in the TN-IIN/IHN group was 84.78%, whereas that in the control group was 28.89%, showing a statistically significant difference ( < 0.01). No significant adverse reactions occurred in either group during the treatment period.
Simultaneous electroacupuncture on the TN and IIN/IHN is effective in treating refractory OAB in women and has good long-term efficacy. This therapy is safe, convenient, and free of significant adverse reactions, providing a new approach for the clinical treatment of refractory OAB in these patients. It significantly improves bladder symptoms and alleviates anxiety and depression, thereby markedly enhancing the patients' quality of life.
本研究旨在观察同时电针刺激胫神经（TN）和髂腹股沟 - 髂腹下神经（IIN/IHN）治疗女性难治性膀胱过度活动症（OAB）的临床疗效。
进行一项前瞻性研究，纳入2022年9月至2023年10月在我院泌尿外科诊断为OAB的94例女性患者。将患者随机分为TN - IIN/IHN组和对照组，每组47例。两组所有患者均接受过抗胆碱能毒蕈碱受体拮抗剂（托特罗定/索利那新）、β3受体激动剂、氟哌噻吨/美利曲辛等基础治疗方案，但效果不佳。TN - IIN/IHN组接受TN和IIN/IHN同时电针治疗，而对照组接受盆底肌生物反馈电刺激。两组均每周治疗3次，共治疗4周。比较并分析治疗前、治疗后及3个月随访时的膀胱症状（24小时排尿日记）、OAB症状评分、OAB生活质量问卷以及焦虑和抑郁评分。同时评估临床疗效。
两组在治疗后及随访时的排尿频率、夜尿次数、尿急、OAB症状评分及平均排尿量均有显著改善（<0.01）。TN - IIN/IHN组的结果明显优于对照组（<0.01）。生活质量评分以及焦虑和抑郁评分显著降低（<0.01），TN - IIN/IHN组的评分显著低于对照组（<0.01）。TN - IIN/IHN组的治疗成功率为84.78%，而对照组为28.89%，差异有统计学意义（<0.01）。治疗期间两组均未发生明显不良反应。
同时电针刺激TN和IIN/IHN治疗女性难治性OAB有效，且具有良好的长期疗效。该疗法安全、便捷，无明显不良反应，为这些患者难治性OAB的临床治疗提供了一种新方法。它能显著改善膀胱症状，缓解焦虑和抑郁，从而明显提高患者的生活质量。
