Serimaa Oona, Keltikangas-Järvinen Liisa, Lyytikäinen Leo-Pekka, Hietala Jarmo, Sormunen Elina, Kähönen Mika, Raitakari Olli, Lehtimäki Terho, Saarinen Aino
Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland.
Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center, Tampere, Finland.
Psychol Med. 2025 May 2;55:e133. doi: 10.1017/S0033291725000911.
Previous evidence has reported associations of a polygenic risk score for schizophrenia (PRS) with negative developmental outcomes, such as psychiatric symptoms, adverse health behaviors, and reduced everyday functioning. We now investigated the relationship of PRS with subjectively experienced well-being.
Participants (n = 1866) came from the prospective population-based Young Finns Study (YFS). Subjective well-being in adulthood was assessed in terms of life satisfaction, optimism, and self-acceptance (when participants were 20-50 years old). A PRS was calculated based on the most recent genome-wide association study on schizophrenia. Covariates included age, sex, early family environment, adulthood socioeconomic factors, and adulthood health behaviors.
The PRS did not predict any domain of subjective well-being, including life satisfaction, optimism, and self-acceptance. After adding covariates in a stepwise manner or including/excluding participants with diagnosed non-affective psychotic disorders, all the associations remained non-significant. Age- and sex-interaction analyses showed that PRS was not associated with subjective well-being in either sex or in any age between 20 and 50 years.
While high PRS has been linked to multiple adversities in previous studies, we did not find any association between high PRS and subjective measures of life satisfaction, optimism, and self-acceptance.
先前的证据报道了精神分裂症多基因风险评分（PRS）与负面发育结果之间的关联，如精神症状、不良健康行为和日常功能下降。我们现在研究了PRS与主观幸福感之间的关系。
参与者（n = 1866）来自基于人群的前瞻性芬兰青年研究（YFS）。在成年期（参与者年龄在20至50岁之间），从生活满意度、乐观主义和自我接纳方面评估主观幸福感。基于最新的精神分裂症全基因组关联研究计算PRS。协变量包括年龄、性别、早期家庭环境、成年期社会经济因素和成年期健康行为。
PRS不能预测主观幸福感的任何方面，包括生活满意度、乐观主义和自我接纳。在逐步加入协变量或纳入/排除已诊断为非情感性精神障碍的参与者后，所有关联仍不显著。年龄和性别交互分析表明，在20至50岁的任何年龄或任何性别中，PRS与主观幸福感均无关联。
虽然在先前的研究中高PRS与多种逆境有关，但我们并未发现高PRS与生活满意度、乐观主义和自我接纳的主观测量指标之间存在任何关联。
