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Key advances and application prospects of PROTAC technologies in the next 5 years.

作者信息

Qin Shuanglin, Xiao Xiaohe

机构信息

Senior Department of Hepatology, China Military Institute of Chinese Materia, The Fifth Medical Center of PLA General Hospital, Beijing, P.R. China.

National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Research Center for Precision Medication of Chinese Medicine, FuRong Laboratory, Hunan University of Chinese Medicine, Changsha, P.R. China.

出版信息

Future Med Chem. 2025 May;17(9):987-989. doi: 10.1080/17568919.2025.2498875. Epub 2025 May 2.

DOI:10.1080/17568919.2025.2498875
PMID:40314207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12091913/
Abstract
摘要

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本文引用的文献

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PROTACs coupled with oligonucleotides to tackle the undruggable.与寡核苷酸偶联的PROTAC用于攻克不可成药靶点。
Bioanalysis. 2025 Feb;17(4):261-276. doi: 10.1080/17576180.2025.2459528. Epub 2025 Feb 3.
2
PROTACs in the treatment of viral diseases.用于治疗病毒性疾病的蛋白水解靶向嵌合体（PROTACs）
Future Med Chem. 2025 Feb;17(3):267-269. doi: 10.1080/17568919.2025.2453418. Epub 2025 Jan 15.
3
Distinct Amino Acid-Based PROTACs Target Oncogenic Kinases for Degradation in Non-Small Cell Lung Cancer (NSCLC).基于独特氨基酸的 PROTACs 靶向降解非小细胞肺癌（NSCLC）中的致癌激酶。
J Med Chem. 2024 Aug 22;67(16):13666-13680. doi: 10.1021/acs.jmedchem.4c00208. Epub 2024 Aug 8.
4
PROTAC technology: From drug development to probe technology for target deconvolution.PROTAC 技术：从药物研发到靶标解析探针技术。
Eur J Med Chem. 2024 Oct 5;276:116725. doi: 10.1016/j.ejmech.2024.116725. Epub 2024 Jul 30.
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Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism.通过靶向蛋白降解机制实现对蚊媒黄病毒的广谱活性。
Nat Commun. 2024 Jun 19;15(1):5179. doi: 10.1038/s41467-024-49161-9.
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Oral Estrogen Receptor PROTAC Vepdegestrant (ARV-471) Is Highly Efficacious as Monotherapy and in Combination with CDK4/6 or PI3K/mTOR Pathway Inhibitors in Preclinical ER+ Breast Cancer Models.口服雌激素受体 PROTAC 降解剂（ARV-471）在 ER+ 乳腺癌模型中作为单药治疗以及与 CDK4/6 或 PI3K/mTOR 通路抑制剂联合使用具有高度疗效。
Clin Cancer Res. 2024 Aug 15;30(16):3549-3563. doi: 10.1158/1078-0432.CCR-23-3465.
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