组织中FOXO1表达、结直肠癌病理特征与患者生存率之间的关联。

Associations between FOXO1 expression in tissue, the pathological characteristics of colorectal cancer, and patient survival.

作者信息

Zhang Genhua, Zhang Zhen, Zhou Yixuan

机构信息

Department of Pathology, Zhejiang Provincial Tongde Hospital, Hangzhou, Zhejiang, China.

Department of Laboratory Medicine, Zhejiang Provincial Tongde Hospital, Hangzhou, Zhejiang, China.

出版信息

Int J Colorectal Dis. 2025 May 2;40(1):105. doi: 10.1007/s00384-025-04896-9.

DOI:10.1007/s00384-025-04896-9

PMID:40314832

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12048467/

Abstract

BACKGROUND

The transcription factor Forkhead box O1 (FOXO1) plays key roles in many biological processes, including metabolic regulation and apoptosis. However, any role in colorectal cancer (CRC) remains to be elucidated.

METHODS

An immunohistochemical tissue microarray was used to measure the expression levels of FOXO1 in cancerous tissues from 76 colorectal cancer patients and 28 paracancerous tissues. The difference in expression in the two tissues was statistically compared, and correlations were sought between FOXO1 concentrations and CRC pathological parameters and prognosis.

RESULTS

FOXO1 positivity was significantly lower in CRC tissues than in paracancerous tissues (59.2% vs 85.7%, P = 0.011). The FOXO1 level of CRC tissues was not significantly correlated with sex, tumour size, pathological or TNM stage, Duke stage for cancer and severity, lymph node metastasis, or vascular invasion. However, low FOXO1 expression predicted poorer differentiation (P = 0.033) and higher nerve invasion (P < 0.001). Kaplan-Meier survival analysis revealed that the 5-year survival rate was significantly higher in patients expressing FOXO1 (75.6%; 34/45) than not (54.8%; 17/31). In the multivariable Cox proportional hazards model analysis, high FOXO1 expression remained independently associated with better overall survival (HR = 0.46, 95% CI 0.25-0.86, P = 0.016).

CONCLUSION

FOXO1 expression is significantly correlated with the pathological features of CRC and patient prognosis.

摘要

背景

转录因子叉头框O1（FOXO1）在包括代谢调节和细胞凋亡在内的许多生物学过程中发挥关键作用。然而，其在结直肠癌（CRC）中的任何作用仍有待阐明。

方法

使用免疫组织化学组织微阵列来测量76例结直肠癌患者癌组织和28例癌旁组织中FOXO1的表达水平。对两种组织中的表达差异进行统计学比较，并寻找FOXO1浓度与CRC病理参数和预后之间的相关性。

结果

CRC组织中FOXO1阳性率显著低于癌旁组织（59.2%对85.7%，P = 0.011）。CRC组织的FOXO1水平与性别、肿瘤大小、病理或TNM分期、癌症杜克分期和严重程度、淋巴结转移或血管侵犯均无显著相关性。然而，低FOXO1表达预示着较差的分化程度（P = 0.033）和较高的神经侵犯率（P < 0.001）。Kaplan-Meier生存分析显示，表达FOXO1的患者5年生存率显著高于未表达者（75.6%；34/45对54.8%；17/31）。在多变量Cox比例风险模型分析中，高FOXO1表达仍与更好的总生存期独立相关（HR = 0.46，95%CI 0.25 - 0.86，P = 0.016）。