Holmes K K, Chen K C, Lipinski C M, Eschenbach D A
J Infect Dis. 1985 Aug;152(2):379-82. doi: 10.1093/infdis/152.2.379.
To explore of the association of bacterial vaginosis with anaerobic bacterial growth in the vagina, we measured the redox potential (Eh) at the vaginal epithelial surface of women with this syndrome. Among normal women, the value for Eh in the vagina ranged from +322 mV to +137 mV (mean, +170 mV); whereas among women with bacterial vaginosis, the Eh ranged from +71 mV to as low as -257 mV (mean, -92 mV). Following successful treatment of the vaginosis with metronidazole, the vaginal Eh increased to a mean of +208 mV. Thus, the low redox potential in the vagina during bacterial vaginosis appears to be due to microbial metabolism in the vagina and does not represent a persistent host factor responsible for the anaerobic vaginal flora. Any host factors responsible for bacterial vaginosis remain to be elucidated.
为了探究细菌性阴道病与阴道内厌氧菌生长之间的关联，我们测量了患有该综合征女性阴道上皮表面的氧化还原电位（Eh）。在正常女性中，阴道内Eh值范围为+322 mV至+137 mV（平均值为+170 mV）；而在患有细菌性阴道病的女性中，Eh值范围为+71 mV至低至 -257 mV（平均值为 -92 mV）。在用甲硝唑成功治疗阴道病后，阴道Eh升高至平均+208 mV。因此，细菌性阴道病期间阴道内低氧化还原电位似乎是由于阴道内的微生物代谢所致，并非是导致阴道厌氧菌群的持续性宿主因素。任何导致细菌性阴道病的宿主因素仍有待阐明。
