H Varun, Singh Adarshlata, Madke Bhushan
Department of Dermatology, Venereology and Leprosy, Datta Meghe Institute of Higher Education and Health, Sawangi (Meghe), Wardha, India.
Photodiagnosis Photodyn Ther. 2025 Jun;53:104617. doi: 10.1016/j.pdpdt.2025.104617. Epub 2025 Apr 30.
Porokeratoses represent a rare spectrum of keratinisation disorders that commonly present as annular, scaly plaques with an atrophic center and either hyper or hypopigmentation. They can be inherited in an autosomal dominant pattern with variable penetrance or occur sporadically. Porokeratosis of Mibelli (PM) is a solitary variant that usually presents in childhood or adolescence and has been attributed to immunosuppression, although the underlying mechanisms remain unclear. Importantly, PM is recognised as a potentially premalignant condition. Ultraviolet-induced fluorescence dermoscopy (UVFD) is a novel, emerging, non-invasive diagnostic tool that can assist in diagnosing various skin lesions. Herein, we report a case of PM affecting the lips, that revealed an unexpected finding on UVFD examination.
汗孔角化症是一种罕见的角化障碍性疾病谱,通常表现为中央萎缩、伴有色素沉着过度或色素减退的环状鳞屑性斑块。它们可呈常染色体显性遗传,外显率可变,也可散发出现。米贝利汗孔角化症(PM)是一种单发的变异型,通常在儿童期或青春期出现,虽然其潜在机制尚不清楚,但一直被认为与免疫抑制有关。重要的是,PM被认为是一种潜在的癌前病变。紫外线诱导荧光皮肤镜检查(UVFD)是一种新型的、新兴的、非侵入性诊断工具,可辅助诊断各种皮肤病变。在此,我们报告一例累及唇部的PM病例,该病例在UVFD检查中发现了一个意外的结果。