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使用计算机辅助手术系统对0至18岁儿童进行肾脏体积测量和预测建模。

Kidney volume measurement and predictive modeling in children aged 0-18 years using a computer-assisted surgery system.

作者信息

Liu Yao, Xu Ning, Yang Xia, Wang Feifei, Wang Fengjiao, Zhu Rongkun, Duan Yuhe, Hao Xiwei, Chen Xue, Bian Chenyuan, Xia Nan, Dong Qian

机构信息

Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University, No. 16, Jiangsu Road, Shinan District, Qingdao, Shandong, China.

Shandong Provincial Key Laboratory of Digital Medicine and Computer-Assisted Surgery, Qingdao, China.

出版信息

Sci Rep. 2025 May 2;15(1):15426. doi: 10.1038/s41598-025-99680-8.

DOI:10.1038/s41598-025-99680-8
PMID:40316663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12048681/
Abstract

This study aimed to measure the normal renal volume in children and adolescents aged 0-18 years from the eastern coastal region of China using the computer-assisted surgery (CAS) system. Accurate measurement of kidney volume is important as a marker for follow-up in patients with congenital anomalies. We established reference ranges for renal volume based on age, height, and weight, and developed predictive models using commonly available clinical data. A total of 803 children and adolescents participated, with clinical data including age, gender, height, weight, body mass index (BMI) and body surface area (BSA) collected. The Hisense CAS system was employed to perform 3D reconstructions of CT images, allowing precise measurement of left and right kidney volumes. Statistical analysis revealed a significant difference in size between the left and right kidneys (P < 0.01), with the left kidney being larger in 79.08% of cases. Age, height, weight, BMI, and BSA were all significantly correlated with kidney volume, with BSA showing the strongest correlation. We developed predictive formulas based on height and weight with good accuracy (R² = 0.896 for left kidney and R² = 0.891 for right kidney). These findings provide reference values for renal volume and offer useful tools for early detection and monitoring of renal abnormalities in the pediatric population.

摘要

本研究旨在利用计算机辅助手术(CAS)系统测量中国东部沿海地区0至18岁儿童和青少年的正常肾体积。准确测量肾脏体积对于先天性异常患者的随访标记物而言很重要。我们基于年龄、身高和体重建立了肾体积的参考范围,并使用常用的临床数据开发了预测模型。共有803名儿童和青少年参与,收集了包括年龄、性别、身高、体重、体重指数(BMI)和体表面积(BSA)在内的临床数据。采用海信CAS系统对CT图像进行三维重建,从而精确测量左右肾体积。统计分析显示左右肾大小存在显著差异(P < 0.01),79.08%的病例中左肾更大。年龄、身高、体重、BMI和BSA均与肾体积显著相关,其中BSA的相关性最强。我们基于身高和体重开发了预测公式,准确性良好(左肾R² = 0.896,右肾R² = 0.891)。这些发现为肾体积提供了参考值,并为儿科人群中肾脏异常的早期检测和监测提供了有用的工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd4/12048681/7a3b57600d57/41598_2025_99680_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd4/12048681/52aa4bda5ae9/41598_2025_99680_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd4/12048681/803d424160e3/41598_2025_99680_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd4/12048681/7a3b57600d57/41598_2025_99680_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd4/12048681/52aa4bda5ae9/41598_2025_99680_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd4/12048681/803d424160e3/41598_2025_99680_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfd4/12048681/7a3b57600d57/41598_2025_99680_Fig3_HTML.jpg

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Application of computer-assisted surgery in pediatric mediastinal tumor surgery.计算机辅助手术在小儿纵隔肿瘤手术中的应用。
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Early childhood height-adjusted total kidney volume as a risk marker of kidney survival in ARPKD.早发性婴儿型多囊肾病患儿身高校正的全肾体积可作为预测患儿肾存活率的风险标志物。
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