Wu Qing, Zhou Yan, Fan Xin, Ma Huan, Gu Wenrui, Sun Fengjun
Department of Pharmacy, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, China International Science and Technology Cooperation Base of Child development and Critical Disorders, Chongqing, China.
Department of Pharmacy, First Affiliated Hospital of Army Medical University, Chongqing, China.
Front Pediatr. 2022 Sep 7;10:989049. doi: 10.3389/fped.2022.989049. eCollection 2022.
Body surface area (BSA) is an important parameter in clinical practice for children. To find out the most accurate BSA formula for Chinese children, nine formulas were compared.
This single-center study comprised children who were diagnosed with acute lymphoblastic leukemia and treated with anticancer agents in a specialized children's hospital in China from January 2017 to December 2020. The BSA values were calculated using the formulas from Boyd, Banerjee and Bhattacharya, Costeff, Fujimoto and Watanabe, Haycock, Gehan and George, Mosteller, Stevenson and a Pediatrics textbook. The arithmetic mean of formulas was calculated as the "gold standard" for comparison.
A total of 666 children (389 males and 277 females) were included. All nine formulas showed a strong positive correlation with the "gold standard." Underestimation was observed with the Banerjee and Bhattacharya, Fujimoto and Watanabe formulas. The Gehan and George formula showed overestimation. Values estimated from the Haycock and Mosteller formulas were the closest to the mean BSA.
The Haycock and Mosteller formulas are the most recommended formulas for Chinese children with hematological malignancies.
体表面积（BSA）是儿童临床实践中的一个重要参数。为了找出最适合中国儿童的BSA公式，对九个公式进行了比较。
这项单中心研究纳入了2017年1月至2020年12月在中国一家专业儿童医院被诊断为急性淋巴细胞白血病并接受抗癌药物治疗的儿童。使用博伊德、班纳吉和巴塔查里亚、科斯特夫、藤本和渡边、海科克、格汉和乔治、莫斯特勒、史蒂文森的公式以及一本儿科学教科书来计算BSA值。将公式的算术平均值计算为用于比较的“金标准”。
共纳入666名儿童（389名男性和277名女性）。所有九个公式与“金标准”均呈现出强烈的正相关。班纳吉和巴塔查里亚、藤本和渡边的公式存在低估情况。格汉和乔治的公式存在高估情况。从海科克和莫斯特勒公式估算出的值最接近平均BSA。
对于患有血液系统恶性肿瘤的中国儿童，海科克和莫斯特勒公式是最值得推荐的公式。
