Janbon C, Coupe M, Espitalier C, Charras C, Dubois A
J Mal Vasc. 1985;10 Suppl A:173-5.
In the course of alcoholic cirrhosis, the low incidence of occlusive arterial diseases in the lower limbs, as well as the analogy in skin lesions between cirrhosis and pregnant women, lead to believe that hyperestrogenism may be common origin of these skin lesions. Research of abnormal microcirculation in the nailfold and oestrogen's receptors have been performed in a cirrhotic (20) and hyperestrogenic (12) population. The capillaroscopic abnormalities have been as follows: fine and short capillaries, oedema slacked circulation, the underlying structure was pale with peripheral halo. These have been observed both in the cirrhotic and hyperestrogenic patients. These oestrogenic receptor in both populations seem mainly localised in the granulosa structure and are more numerous than normal. Capillaroscopic features on the cirrhotic patients were similar to those on hyperestrogenic patients. The presence of oestrogenic receptors in the skin bears no particular significance at the present time.
在酒精性肝硬化病程中，下肢闭塞性动脉疾病发病率低，以及肝硬化患者与孕妇皮肤病变的相似性，使人认为高雌激素血症可能是这些皮肤病变的共同根源。对20例肝硬化患者和12例高雌激素血症患者进行了甲襞微循环异常及雌激素受体的研究。毛细血管镜检查异常表现如下：毛细血管纤细短小、水肿、血流缓慢，其底层结构苍白，周边有光晕。在肝硬化患者和高雌激素血症患者中均观察到这些表现。这两组人群中的雌激素受体似乎主要定位于颗粒结构，且数量多于正常。肝硬化患者的毛细血管镜特征与高雌激素血症患者相似。目前皮肤中雌激素受体的存在并无特别意义。
